Azeredo Francine Johansson, Dalla Costa Teresa, Derendorf Hartmut
Programa de Pós-Graduação em Ciências Farmacêuticas, UFRGS, Porto Alegre, Brazil.
Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610, USA.
Clin Pharmacokinet. 2014 Mar;53(3):205-212. doi: 10.1007/s40262-014-0131-8.
Diagnostic and therapeutic decisions in medical practice are still generally based on blood concentrations of drugs and/or biomolecules despite the knowledge that biochemical events and pharmacological effects usually take place in tissue rather than in the bloodstream. Microdialysis is a semi-invasive technique that is able to measure concentrations of the free, active drug or endogenous compounds in almost all human tissues and organs. It is currently being used to monitor brain metabolic processes and quantify tissue biomarkers, and determine transdermal drug distribution and tissue pharmacokinetics, confirming its importance as a widely used sampling technique in clinical drug monitoring and drug development as well as therapy and disease follow-up, contributing to rationalizing drug dosing regimens and influencing the clinical decision-making process.
尽管人们知道生化事件和药理作用通常发生在组织而非血液中，但医学实践中的诊断和治疗决策仍然普遍基于药物和/或生物分子的血液浓度。微透析是一种半侵入性技术，能够测量几乎所有人体组织和器官中游离的、活性药物或内源性化合物的浓度。它目前正被用于监测脑代谢过程、量化组织生物标志物、确定透皮药物分布和组织药代动力学，证实了其作为临床药物监测、药物开发以及治疗和疾病随访中广泛使用的采样技术的重要性，有助于使给药方案合理化并影响临床决策过程。
