Bozzetti P, Buscaglia M, Cetin I, Marconi A M, Nicolini U, Pardi G, Makowski E L, Battaglia F C
1st Department of Obstetrics-Gynecology, University of Milan School of Medicine, Italy.
Biol Neonate. 1987;52(4):188-97. doi: 10.1159/000242709.
Respiratory gases, acid-base balance, and lactate and hemoglobin concentrations were measured in 14 fetal blood samples between 17 and 21 weeks of gestation. The samples were obtained at the time of fetoscopy performed for prenatal diagnosis. Results have been compared with two reference groups: (a) 4 patients in whom fetal cord blood sampling was performed at 32-36 weeks of gestation, and (b) 10 patients at the time of elective cesarean section, 35-39 weeks. PO2 and oxygen saturations were significantly higher and hemoglobin concentration lower in the mid-gestation fetus. Acid-base balance was not significantly different. There was a significant correlation between maternal and fetal hemoglobin concentrations. The oxygen affinity of fetal blood was not significantly different from that described for term fetuses with a oxygen saturation of less than 90%.
对14例妊娠17至21周的胎儿血样进行了呼吸气体、酸碱平衡以及乳酸和血红蛋白浓度的测定。这些样本是在为进行产前诊断而实施胎儿镜检查时获取的。研究结果已与两个参照组进行了比较：（a）4例在妊娠32至36周时进行胎儿脐血采样的患者，以及（b）10例在妊娠35至39周进行择期剖宫产时的患者。孕中期胎儿的氧分压和氧饱和度显著更高，而血红蛋白浓度更低。酸碱平衡无显著差异。母体和胎儿血红蛋白浓度之间存在显著相关性。胎儿血液的氧亲和力与报道的足月胎儿氧饱和度低于90%时的氧亲和力无显著差异。
