Batra S
Department of Obstetrics and Gynaecology, University Hospital, Lund, Sweden.
Br J Pharmacol. 1987 Oct;92(2):389-92. doi: 10.1111/j.1476-5381.1987.tb11335.x.
1 The effect of in vivo oestrogen treatment on both 45Ca influx in myometrial strips and the kinetics of [3H)-nitrendipine binding in the isolated plasma membrane (PM) was studied. 2 After four days of continuous oestrogen treatment of ovariectomized rats, 45Ca influx in both resting (unstimulated) and K-stimulated myometrium was substantially increased. 3 Oestrogen treatment significantly increased the density in PM of nitrendipine binding sites and also caused a slight and insignificant increase in the affinity for nitrendipine. 4 The data suggest that the increase in Ca entry following oestrogen treatment probably results from an increase in calcium channel density.
1 研究了体内雌激素治疗对子宫肌条中45Ca内流以及分离的质膜（PM）中[3H]-尼群地平结合动力学的影响。2 对去卵巢大鼠连续进行四天雌激素治疗后，静息（未刺激）和K刺激的子宫肌层中的45Ca内流均显著增加。3 雌激素治疗显著增加了PM中尼群地平结合位点的密度，并且对尼群地平的亲和力也有轻微且不显著的增加。4 数据表明，雌激素治疗后钙内流的增加可能是由于钙通道密度增加所致。
