雌激素使子宫平滑肌中钙内流及钙通道密度增加。
Increase by oestrogen of calcium entry and calcium channel density in uterine smooth muscle.
作者信息
Batra S
机构信息
Department of Obstetrics and Gynaecology, University Hospital, Lund, Sweden.
出版信息
Br J Pharmacol. 1987 Oct;92(2):389-92. doi: 10.1111/j.1476-5381.1987.tb11335.x.
Abstract
1 The effect of in vivo oestrogen treatment on both 45Ca influx in myometrial strips and the kinetics of [3H)-nitrendipine binding in the isolated plasma membrane (PM) was studied. 2 After four days of continuous oestrogen treatment of ovariectomized rats, 45Ca influx in both resting (unstimulated) and K-stimulated myometrium was substantially increased. 3 Oestrogen treatment significantly increased the density in PM of nitrendipine binding sites and also caused a slight and insignificant increase in the affinity for nitrendipine. 4 The data suggest that the increase in Ca entry following oestrogen treatment probably results from an increase in calcium channel density.
摘要
1 研究了体内雌激素治疗对子宫肌条中45Ca内流以及分离的质膜（PM）中[3H]-尼群地平结合动力学的影响。2 对去卵巢大鼠连续进行四天雌激素治疗后，静息（未刺激）和K刺激的子宫肌层中的45Ca内流均显著增加。3 雌激素治疗显著增加了PM中尼群地平结合位点的密度，并且对尼群地平的亲和力也有轻微且不显著的增加。4 数据表明，雌激素治疗后钙内流的增加可能是由于钙通道密度增加所致。
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Increase by oestrogen of calcium entry and calcium channel density in uterine smooth muscle.雌激素使子宫平滑肌中钙内流及钙通道密度增加。
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Characterization of [3H]-nitrendipine binding to uterine smooth muscle plasma membrane and its relevance to inhibition of calcium entry.[3H]-尼群地平与子宫平滑肌质膜结合的特性及其与钙内流抑制的相关性。
Br J Pharmacol. 1985 Aug;85(4):767-74. doi: 10.1111/j.1476-5381.1985.tb11074.x.
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Calcium exchange in vascular smooth muscle, action of noradrenaline and lanthanum.血管平滑肌中的钙交换、去甲肾上腺素和镧的作用。
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