Batra S, Sjöberg N O, Thorbert G
Endocrinology. 1978 Jan;102(1):268-72. doi: 10.1210/endo-102-1-268.
After a single injection of Estradurin (polyestradiolphosphate), rabbit plasma 17 beta-estradiol (E2) levels rose to a maximum in 3 days and were maintained for at least a 13-day period. The uterine E2 concentration rose slowly so that at day 12 the tissue/plasma E2 ratio was similar to that in untreated controls. The gain in tissue weight after the Estradurin injection correlated well with the increase in tissue E2 concentration. In a group of rabbits to which progesterone (P) was administered 7 days after Estradurin injection, the E2 concentration in plasma did not change significantly. However, the tissue E2 concentration showed a significant decrease after four daily injections of P. When P injections were halted (progesterone withdrawal) for 2 days, the tissue E2 levels rose and were greater than those found in the group not receiving P. These levels were significantly higher than those found in animals which had received daily injections of P for 2 or 4 days. These results indicate that P is able to suppress the accumulation of E2 by uterine tissue, in agreement with published evidence that P is able to reduce the levels of cytoplasmic E2 receptors.
单次注射雌二醇磷酯（Estradurin）后，兔血浆17β-雌二醇（E2）水平在3天内升至最高，并维持至少13天。子宫E2浓度上升缓慢，以至于在第12天时组织/血浆E2比值与未处理的对照组相似。注射雌二醇磷酯后组织重量的增加与组织E2浓度的增加密切相关。在雌二醇磷酯注射7天后给予孕酮（P）的一组兔子中，血浆中E2浓度没有显著变化。然而，在每日注射4次P后，组织E2浓度显著下降。当停止注射P（孕酮撤药）2天时，组织E2水平上升，且高于未接受P的组。这些水平显著高于接受P每日注射2天或4天的动物。这些结果表明，P能够抑制子宫组织中E2的积累，这与已发表的证据一致，即P能够降低细胞质E2受体的水平。
