Hattab Faiez N
BDS, PhD, Odont. Dr. Professor and Senior Consultant in Restorative and Pediatric Dentistry, private clinic. Amman, Jordan.
J Clin Exp Dent. 2013 Dec 1;5(5):e239-44. doi: 10.4317/jced.51214.
To provide a description of mesiodistal crown diameters (MD) and tooth-size discrepancy (TSD) of the permanent dentition in patients with thalassemia major (TM) and to compare the results with those of unaffected control group.
The sample consisted of 46 thalassemic patients, 25 males and 21 females aged 7.3 to 23.7 years (mean ± SD = 11.2 ± 3.9 years) and control group matched by age and sex. Dental casts of the participants were measured for MD, using a digital sliding caliper. Descriptive statistics were computed for each individual tooth. Student t-test was used for comparison of mean values between males and females as well as between thalassemic and control groups. The differences between sets of data were evaluated by analysis of variance (ANOVA).
All means for MD of thalassemic males and females were smaller than their controls, with 20 of the 24 comparisons being statistically significant (ranged from P<0.05 to P<0.001). In both thalassemic and control groups, males exhibited significantly larger MD than females in most instances. Canines displayed the most sexual dimorphic teeth in the dentition. Lateral incisors showed the greatest variability indicated by the coefficient of variation, while the first molars were the least variable teeth (7.6% vs. 5.3%). There were no statistically significant differences in the anterior and overall tooth-size discrepancy ratios between sexes or between thalassemic and control groups. The mean anterior ratio (79.5%) and overall ratio (92.4%) of the control group were significantly larger than of Bolton ratios; P< 0.001 and P<0.05, respectively.
The present study demonstrated that thalassemic males and females exhibited significantly smaller MD than the control group. The TSD ratios in both thalassemic and control groups were significantly larger than those of Bolton sample. These findings should be taken into account when planning orthodontic treatment for thalassemic patients. Key words:Permanent dentition, tooth size, thalassemia major.
描述重型地中海贫血（TM）患者恒牙列的近远中牙冠直径（MD）及牙大小不调（TSD）情况，并将结果与未受影响的对照组进行比较。
样本包括46例地中海贫血患者，其中25例男性和21例女性，年龄7.3至23.7岁（平均±标准差 = 11.2±3.9岁），以及按年龄和性别匹配的对照组。使用数字游标卡尺测量参与者的牙模MD。计算每颗牙齿的描述性统计数据。采用学生t检验比较男性与女性以及地中海贫血组与对照组之间的平均值。通过方差分析（ANOVA）评估数据集之间的差异。
地中海贫血男性和女性的所有MD平均值均小于其对照组，24项比较中有20项具有统计学意义（范围从P<0.05至P<0.001）。在地中海贫血组和对照组中，大多数情况下男性的MD均显著大于女性。犬齿是牙列中表现出最大性别差异的牙齿。侧切牙的变异系数显示出最大的变异性，而第一磨牙是变异性最小的牙齿（7.6%对5.3%）。性别之间或地中海贫血组与对照组之间的前牙及全牙大小不调比率无统计学显著差异。对照组的平均前牙比率（79.5%）和全牙比率（92.4%）显著大于博尔顿比率；分别为P<0.001和P<0.05。
本研究表明，地中海贫血男性和女性的MD显著小于对照组。地中海贫血组和对照组的TSD比率均显著大于博尔顿样本。在为地中海贫血患者规划正畸治疗时应考虑这些发现。关键词：恒牙列、牙大小、重型地中海贫血
