Anding Ralf, Tabaza Ruth, Staat Manfred, Trenz Eva, Lohmann Philipp, Klinge Uwe, Kirschner-Hermanns Ruth
Department of Neuro-Urology, University Hospital, Rheinische Friedrich-Wilhelms-University, 53127 Bonn, Germany.
Institute of Bioengineering, FH Aachen University of Applied Sciences, Juelich Campus, 52428 Juelich, Germany.
Biomed Res Int. 2013;2013:401417. doi: 10.1155/2013/401417. Epub 2013 Dec 22.
To develop a method for in vitro testing to compare different intracorporeal anchoring systems (AS) used, for example, in single-incision slings or vaginal meshes. Intracorporeal fixation needs reliable anchorage systems, which keep the implant in the operative and early postoperative phase in place. Up to now, the impact of the design of current anchor systems and their capability to provide sufficient retention forces is not known.
Four AS ("PelFix", "Surelift", "TFS", and "MiniArc") were evaluated in an animal model and a ballistic gelatine model with pull-out tests. We performed ANOVA with post hoc Bonferroni. Results were presented as mean values whereby a significance level of <0.05 was considered significant.
The four systems showed significantly different pull-out forces. Depending on mesh structure, size, and form of the AS, mechanical strain resulted in deformation with local peak stresses. Under the condition of form stability, relative differences of pull-out forces did not change in different tissues.
Reliable testing of different AS in their ability to keep mesh implants in place can be done in animal models and in especially designed ballistic gelatine. These methods of testing will help to modify AS in novel pelvic floor implants.
开发一种体外测试方法，以比较不同的体内锚定系统（AS），例如用于单切口吊带或阴道网片的系统。体内固定需要可靠的锚定系统，该系统可在手术期和术后早期将植入物固定在原位。到目前为止，尚不清楚当前锚定系统的设计及其提供足够保持力的能力的影响。
在动物模型和弹道明胶模型中通过拔出试验对四种AS（“PelFix”、“Surelift”、“TFS”和“MiniArc”）进行评估。我们使用事后邦费罗尼检验进行方差分析。结果以平均值表示，显著性水平<0.05被认为具有显著性。
这四种系统显示出显著不同的拔出力。根据AS的网片结构、尺寸和形式，机械应变会导致变形并产生局部峰值应力。在形状稳定的条件下，不同组织中拔出力的相对差异不变。
在动物模型和特别设计的弹道明胶中，可以对不同AS将网片植入物固定在位的能力进行可靠测试。这些测试方法将有助于改进新型盆底植入物中的AS。
