Tian Chang-Rong, Qian Li, Du Chun-Ling, Shen Xiao-Zhu
Department of Geriatrics, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.
Department of Microbiology Laboratory, The Second People's Hospital of Lianyungang, 41 East Hailian Road, Xinpu 222006, China.
Int J Biol Macromol. 2014 Apr;65:107-9. doi: 10.1016/j.ijbiomac.2014.01.025. Epub 2014 Jan 20.
Uric acid is the end product of nucleic acid catabolism for humanity. Serum uric acid level has been suggested to be associated with nonalcoholic fatty liver disease (NAFLD). This study aims to examine the association between serum uric acid levels and NAFLD in subjects of different ages. A cross-sectional study was performed among the patients of different ages with NAFLD (abnormal group) or without NAFLD (normal group) in Lianyungang, Jiangsu, China. The levels of serum uric acid, total cholesterol, triglyceride, and low density lipoprotein in the abnormal group were significantly higher than those in the normal group, while the level of high density lipoprotein in the abnormal group was significantly lower than that in the normal group (p<0.05). The serum uric acid prevalence, total cholesterol, triglyceride, high density lipoprotein, and low density lipoprotein in the abnormal group was significantly higher than those in the normal group (p<0.05). The serum uric acid, total cholesterol, triglyceride, and low density lipoprotein levels and prevalence rates in elderly patients were higher than younger and middle aged patients. Serum uric acid level is highly associated with NAFLD in patients of different ages.
尿酸是人类核酸分解代谢的终产物。血清尿酸水平被认为与非酒精性脂肪性肝病（NAFLD）有关。本研究旨在探讨不同年龄段人群血清尿酸水平与NAFLD之间的关联。在中国江苏连云港，对不同年龄段患有NAFLD的患者（异常组）和未患NAFLD的患者（正常组）进行了一项横断面研究。异常组的血清尿酸、总胆固醇、甘油三酯和低密度脂蛋白水平显著高于正常组，而异常组的高密度脂蛋白水平显著低于正常组（p<0.05）。异常组的血清尿酸患病率、总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白均显著高于正常组（p<0.05）。老年患者的血清尿酸、总胆固醇、甘油三酯和低密度脂蛋白水平及患病率高于年轻和中年患者。血清尿酸水平与不同年龄段患者的NAFLD高度相关。
