Cai Wen, Song Jiang-mei, Zhang Bei, Sun Yu-ping, Yao Hua, Zhang Yue-xin
School of Nursing, Xinjiang Medical University, No. 168 Youhao South Road, Urumqi, Xinjiang 830000, China.
Department of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
ScientificWorldJournal. 2014 Jan 2;2014:393628. doi: 10.1155/2014/393628. eCollection 2014.
To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of serum uric acid level with NAFLD in Uygur people, Xinjiang.
A total of 2241 Uyghur persons (1214 males and 1027 females) were interviewed for physical checkups from 2011 to 2012. The clinical data of questionnaire survey, body mass index (BMI), abdominal circumference, blood pressure, blood sugar, blood lipid, and serum uric acid level were collected for analysis.
The prevalence rates of NAFLD determined by abdominal ultrasound examination and hyperuricemia were 43.9% and 8.4%, respectively. The persons with NAFLD had significantly higher serum uric acid levels than those without NAFLD (320 ± 88 versus 254 ± 80 μ mol/L; P < 0.001). The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than that in those without hyperuricemia (78.19% versus 40.83%; P < 0.001), and the prevalence rate increased with progressively higher serum uric acid levels (P < 0.001). Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD (odds ratio (OR): 2.628, 95% confidence interval (CI): 1.608-4.294, and P < 0.001).
Serum uric acid level was significantly associated with NAFLD, and the prevalence rate of NAFLD increased with progressively higher serum uric acid levels.
调查新疆维吾尔族人群中非酒精性脂肪性肝病（NAFLD）的患病率以及血清尿酸水平与NAFLD的相关性。
2011年至2012年期间，共对2241名维吾尔族人（1214名男性和1027名女性）进行了体检访谈。收集问卷调查、体重指数（BMI）、腹围、血压、血糖、血脂和血清尿酸水平的临床资料进行分析。
腹部超声检查确定的NAFLD患病率和高尿酸血症患病率分别为43.9%和8.4%。患有NAFLD的人血清尿酸水平显著高于未患NAFLD的人（320±88对254±80μmol/L；P<0.001）。高尿酸血症患者的NAFLD患病率显著高于无高尿酸血症患者（78.19%对40.83%；P<0.001），且患病率随血清尿酸水平逐渐升高而增加（P<0.001）。多元回归分析显示，高尿酸血症与NAFLD风险增加相关（比值比（OR）：2.628，95%置信区间（CI）：1.608 - 4.294，P<0.001）。
血清尿酸水平与NAFLD显著相关，且NAFLD患病率随血清尿酸水平逐渐升高而增加。
