Talarowska Monika, Bobińska Kinga, Zajączkowska Marlena, Su Kuan-Pin, Maes Michael, Gałecki Piotr
Department of Adult Psychiatry, Medical University of Łódź, Łódź, Poland.
Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
Med Sci Monit. 2014 Jan 24;20:110-5. doi: 10.12659/MSM.889853.
Data show that up to 38.2% of the European population have a mental disorder and that recurrent depressive disorder (rDD) is among the most commonly diagnosed disabling diseases. Over the last few years, neurocognitive impairments in rDD have become a new research front focusing on the role of cognitive decline during the course of rDD and in relation to its clinical presentation and prognosis. Both immune-inflammatory and oxidative and nitrosative stress (O&NS) processes potentially play a role in development of cognitive dysfunction in rDD. New evidence shows that chronic inflammatory and O&NS reactions occur in the brains of patients with neurodegenerative disorders and those with rDD. This narrative review presents the current state of knowledge on the possible impact of selected inflammatory and O&NS enzymes on cognitive functioning in patients with rDD. We focus on manganese superoxide dismutase (MnSOD), inducible nitric oxide synthase (iNOS), and myeloperoxidase (MPO).
数据显示，高达38.2%的欧洲人口患有精神障碍，而复发性抑郁症（rDD）是最常被诊断出的致残性疾病之一。在过去几年中，rDD中的神经认知障碍已成为一个新的研究前沿，聚焦于rDD病程中认知衰退的作用及其与临床表现和预后的关系。免疫炎症以及氧化和亚硝化应激（O&NS）过程可能在rDD认知功能障碍的发展中起作用。新证据表明，慢性炎症和O&NS反应发生在神经退行性疾病患者和rDD患者的大脑中。这篇叙述性综述介绍了关于选定的炎症和O&NS酶对rDD患者认知功能可能影响的当前知识状态。我们重点关注锰超氧化物歧化酶（MnSOD）、诱导型一氧化氮合酶（iNOS）和髓过氧化物酶（MPO）。
