Krivosova Michaela, Gondas Eduard, Murin Radovan, Dohal Matus, Ondrejka Igor, Tonhajzerova Ingrid, Hutka Peter, Ferencova Nikola, Visnovcova Zuzana, Hrtanek Igor, Mokry Juraj
Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.
Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovakia.
Diagnostics (Basel). 2022 Mar 26;12(4):813. doi: 10.3390/diagnostics12040813.
Major depressive disorder (MDD) is a serious mental disease with a pathophysiology that is not yet fully clarified. An increasing number of studies show an association of MDD with energy metabolism alteration and the presence of oxidative stress. We aimed to evaluate plasma levels of 3-hydroxybutyrate (3HB), NADH, myeloperoxidase, and dityrosine (di-Tyr) in adolescent and adult patients with MDD, compare them with healthy age-matched controls, and assess the effect of antidepressant treatment during hospitalisation on these levels. In our study, plasmatic levels of 3HB were elevated in both adolescents (by 55%; p = 0.0004) and adults (by 88%; p < 0.0001) with MDD compared to controls. Levels of dityrosine were increased in MDD adults (by 19%; p = 0.0092) but not adolescents. We have not found any significant effect of antidepressants on the selected parameters during the short observation period. Our study supports the findings suggesting altered energy metabolism in MDD and demonstrates its presence independently of the age of the patients.
重度抑郁症（MDD）是一种严重的精神疾病，其病理生理学尚未完全阐明。越来越多的研究表明，MDD与能量代谢改变和氧化应激的存在有关。我们旨在评估青少年和成年MDD患者血浆中3-羟基丁酸（3HB）、还原型辅酶I（NADH）、髓过氧化物酶和二酪氨酸（di-Tyr）的水平，将其与年龄匹配的健康对照进行比较，并评估住院期间抗抑郁治疗对这些水平的影响。在我们的研究中，与对照组相比，青少年（升高55%；p = 0.0004）和成年MDD患者（升高88%；p < 0.0001）的血浆3HB水平均升高。MDD成年患者的二酪氨酸水平升高（升高19%；p = 0.0092），但青少年患者未升高。在短期观察期内，我们未发现抗抑郁药对所选参数有任何显著影响。我们的研究支持了提示MDD患者能量代谢改变的研究结果，并表明这种改变与患者年龄无关。
