Jeenger Jitendra, Singroha Vikas, Sharma Manu, Mathur Devendra Mohan
Department of Psychiatry, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.
Indian J Psychiatry. 2018 Jul-Sep;60(3):334-339. doi: 10.4103/psychiatry.IndianJPsychiatry_169_18.
The aim of the study is to assess and compare serum C-reactive protein (CRP), brain derived neurotrophic factor (BDNF), and interleukin-2 (IL-2) levels in patients with first-episode depression (FED), recurrent depressive disorder (RDD), and healthy controls (HCs) and to determine the relationship between the above-specified inflammatory markers, severity of depression, and stressful life events.
Consecutive drug-naive patients with FED and RDD ( = 85) and 50 HCs were studied. Serum concentrations of CRP, brain-derived nerve growth factor (BDNF), and IL-2 were measured. All participants were assessed using Mini-International Neuropsychiatric Interview Plus, Beck's depression inventory, and presumptive stressful life events scale.
The FED and RDD groups had statistically significant lower serum concentration of BDNF and higher IL-2 compared to the HC group, whereas no statistically significant difference was observed with regard to CRP level. No statistically significant differences were observed with regard to the severity of depression and serum concentrations of CRP, BDNF, and IL-2 in the FED and RDD groups. No significant correlation was found between severity of depression and serum concentration of CRP, BDNF, and IL-2 in both the groups. Serum CRP concentration was significantly higher in patients with ≥2 stressful life events. No significant difference was observed between number of stressful life events and BDNF and IL-2 in patients with depression.
FED and RDD are associated with lower serum concentration of BDNF and higher IL-2 compared to the HCs, whereas there appears no difference with regard to CRP level. Multicentric studies are needed to further elucidate the role of inflammatory markers in depression.
本研究旨在评估并比较首发抑郁症（FED）、复发性抑郁症（RDD）患者及健康对照者（HCs）的血清C反应蛋白（CRP）、脑源性神经营养因子（BDNF）和白细胞介素-2（IL-2）水平，并确定上述炎症标志物、抑郁严重程度及应激性生活事件之间的关系。
对连续入选的未服用过药物的FED和RDD患者（n = 85）及50名HCs进行研究。检测血清中CRP、脑源性神经生长因子（BDNF）和IL-2的浓度。所有参与者均使用简明国际神经精神病学访谈升级版、贝克抑郁量表和假定应激性生活事件量表进行评估。
与HC组相比，FED组和RDD组血清BDNF浓度在统计学上显著降低，IL-2水平升高，而CRP水平未观察到统计学上的显著差异。FED组和RDD组在抑郁严重程度以及CRP、BDNF和IL-2血清浓度方面未观察到统计学上的显著差异。两组中抑郁严重程度与CRP、BDNF和IL-2血清浓度之间均未发现显著相关性。应激性生活事件≥2次的患者血清CRP浓度显著更高。抑郁症患者的应激性生活事件数量与BDNF和IL-2之间未观察到显著差异。
与HCs相比，FED和RDD与较低的血清BDNF浓度和较高的IL-2相关，而CRP水平似乎没有差异。需要多中心研究进一步阐明炎症标志物在抑郁症中的作用。
