Mehrotra Rajnish, Agarwal Anil, Bargman Joanne M, Himmelfarb Jonathan, Johansen Kirsten L, Watnick Suzanne, Work Jack, McBryde Kevin, Flessner Michael, Kimmel Paul L
Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington;, †Ohio State University, Columbus, Ohio;, ‡University Health Network, Toronto, Ontario, Canada;, §University of California, San Francisco, California;, ‖Oregon Health and Science University, Portland, Oregon;, ¶Emory University, Atlanta, Georgia, *National Institute of Diabetes, Digestive, and Kidney Disease, National Institutes of Health, Bethesda, Maryland.
Clin J Am Soc Nephrol. 2014 Apr;9(4):812-4. doi: 10.2215/CJN.12601213. Epub 2014 Jan 23.
The National Institute of Diabetes, Digestive, and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives that would improve our understanding of kidney function and disease. Kidney Research National Dialogue participants identified the need to improve outcomes in ESRD by decreasing mortality and morbidity and enhancing quality of life as high priority areas in kidney research. To reach these goals, we must identify retained toxins in kidney disease, accelerate technologic advances in dialysate composition and devices to remove these toxins, advance vascular access, and identify measures that decrease the burden of disease in maintenance dialysis patients. Together, these research objectives provide a path forward for improving patient-centered outcomes in ESRD.
美国国立糖尿病、消化和肾脏疾病研究所资助的肾脏研究全国对话邀请科学界制定研究目标并确定其优先顺序,以增进我们对肾脏功能和疾病的了解。肾脏研究全国对话的参与者认为,通过降低死亡率和发病率以及提高生活质量来改善终末期肾病的治疗效果,是肾脏研究的高度优先领域。为实现这些目标,我们必须识别肾脏疾病中潴留的毒素,加速透析液成分和设备的技术进步以清除这些毒素,改进血管通路,并确定减轻维持性透析患者疾病负担的措施。这些研究目标共同为改善终末期肾病以患者为中心的治疗效果提供了一条前进的道路。