CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101 (PR China), Fax: (+86) 532-80662724.
ChemSusChem. 2014 Jan;7(1):105-9. doi: 10.1002/cssc.201300815. Epub 2013 Nov 20.
The direct α-alkylation of ketones with alcohols has emerged as a new green protocol to construct C-C bonds with H2 O as the sole byproduct. In this work, a very simple and convenient Pd/C catalytic system for the direct α-alkylation of ketones with primary alcohols in pure water is developed. Based on this catalytic system, aqueous mixtures of dilute acetone, 1-butanol, and ethanol (mimicking ABE fermentation products) can be directly transformed into C5 -C11 or longer-chain ketones and alcohols, which are precursors to fuels.
酮与醇的直接 α-烷基化反应作为一种新型的绿色合成方法，以 H2O 为唯一副产物，构建 C-C 键。在这项工作中，开发了一种非常简单方便的 Pd/C 催化体系，用于在纯水中实现酮与伯醇的直接 α-烷基化反应。基于该催化体系，稀丙酮、1-丁醇和乙醇的水相混合物（模拟 ABE 发酵产物）可以直接转化为 C5-C11 或更长链的酮和醇，这些物质是燃料的前体。
