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从裸露到覆盖:经导管支架植入治疗主动脉缩窄的15年单中心经验及随访

From bare to covered: 15-year single center experience and follow-up in trans-catheter stent implantation for aortic coarctation.

作者信息

Butera Gianfranco, Manica João Luiz Langer, Marini Davide, Piazza Luciane, Chessa Massimo, Filho Raul Ivo Rossi, Sarmento Leite Rogério E, Carminati Mario

机构信息

Department of Pediatric Cardiology and Adults with Congenital Heart Disease, Policlinico San Donato IRCCS, Milan, Italy.

出版信息

Catheter Cardiovasc Interv. 2014 May 1;83(6):953-63. doi: 10.1002/ccd.25404. Epub 2014 Feb 4.

Abstract

BACKGROUND

Bare stents has become the first line therapy for aortic coarctation. Covered stents has been reported more recently in clinical practice.

OBJECTIVES

The present study, reports comparatively 15-year experience of bare and covered stent implantation for aortic coarctation in a single tertiary referral center.

METHODS

From 1997 to 2011, 143 patients with native or postoperative aortic coarctation were treated at our institution. Seventy-one subjects (median age 17 years (range from 4 to 70 years) underwent bare stent implantation (Group 1) while 72 patients (median age of 17.5 years (range from 6 to 68 years) underwent covered stent implantation (Group 2).

RESULTS

Success rate in the whole group was 95%. More complex and tighter coarctations were treated using covered stents. Incidence of related-procedure adverse events was higher in Group 1 than in group 2 (21.1% vs. 8.3% P = 0.035). Aortic wall complications occurred in 7% of patients in Group 1 (one death) and 0% in Group 2 (P = 0.028). Subjects in Group 1 had a longer follow-up (median 85 vs. 35 months; P < 0.001). Independent predictors associated with reintervention included the presence of complex lesions (HR: 2.70; CI: 1.15-6.32), balloon diameter used <14 mm (HR: 3.76; CI: 1.48-9.55), and immediate residual gradient >10 mm Hg (HR: 4.30; CI: 1.96-9.47).

CONCLUSIONS

Both bare and covered stent implantation for aortic coarctation is a safe and efficacious treatment. By using covered stent implantation the spectrum of patients treated has increased with lower rates of acute and late complications.

摘要

背景

裸支架已成为主动脉缩窄的一线治疗方法。近年来有报道称覆膜支架已应用于临床实践。

目的

本研究报告了在一家单一的三级转诊中心对主动脉缩窄患者进行裸支架和覆膜支架植入的15年对比经验。

方法

1997年至2011年,我院共治疗了143例原发性或术后主动脉缩窄患者。71例患者(中位年龄17岁,范围4至70岁)接受裸支架植入(第1组),72例患者(中位年龄17.5岁,范围6至68岁)接受覆膜支架植入(第2组)。

结果

全组成功率为95%。使用覆膜支架治疗的主动脉缩窄更为复杂和严重。第1组相关手术不良事件的发生率高于第2组(21.1%对8.3%,P = 0.035)。第1组7%的患者发生主动脉壁并发症(1例死亡),第2组为0%(P = 0.028)。第1组患者的随访时间更长(中位时间85个月对35个月;P < 0.001)。与再次干预相关的独立预测因素包括复杂病变的存在(HR:2.70;CI:1.15 - 6.32)、使用的球囊直径<14 mm(HR:3.76;CI:1.48 - 9.55)以及即刻残余压差>10 mmHg(HR:4.30;CI:1.96 - 9.47)。

结论

主动脉缩窄的裸支架和覆膜支架植入都是安全有效的治疗方法。通过使用覆膜支架植入,可治疗的患者范围扩大,急性和晚期并发症发生率降低。

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