Lee Sik, Kang Kyung Pyo, Kang Sung Kyew
Division of Nephrology, Department of Internal Medicine, Chonbuk National University Medical School, Chonbuk, Korea.
Electrolyte Blood Press. 2006 Mar;4(1):44-6. doi: 10.5049/EBP.2006.4.1.44.
The anion gap in the serum is useful in the interpretation of acid-base disorders and in the diagnosis of other conditions. In the early 1980s, ion-selective electrodes for specific ionic species were introduced for the measurement of serum electrolytes. This new method has caused a shift of the anion gap from 12±4 mEq/L down 6±3 mEq/L. It is worthy for clinicians to understand the range of normal anion gap and the measuring methods for serum sodium and chloride in the laboratories that support their practice. While an increase in the anion gap is almost always caused by retained unmeasured anions, a decrease in the anion gap can be generated by multiple mechanisms.
血清阴离子间隙有助于酸碱平衡紊乱的诊断及其他疾病的诊断。20世纪80年代初，用于测量血清电解质的特定离子种类的离子选择电极被引入。这种新方法导致阴离子间隙从12±4 mEq/L降至6±3 mEq/L。临床医生了解支持其实践的实验室中正常阴离子间隙范围以及血清钠和氯的测量方法是很有必要的。虽然阴离子间隙增加几乎总是由未测定的阴离子潴留引起，但阴离子间隙降低可由多种机制导致。
