Doyle-Thomas Krissy A R, Card Dallas, Soorya Latha V, Wang A Ting, Fan Jin, Anagnostou Evdokia
Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, 150 Kilgour Road, Toronto, Ontario, Canada M4G 1R8.
Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Canada M5G 1X8 ; Neurosciences & Mental Health Program, Research Institute, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Canada M5G 1X8.
Res Autism Spectr Disord. 2014 Jan;8(1):44-51. doi: 10.1016/j.rasd.2013.10.003.
Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7-18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences.
针对自闭症的结构性神经影像学研究报告称，与症状学相关的深部脑结构存在异常体积。对于这些区域的代谢变化、它们如何随年龄和性别变化，以及/或者与临床行为的关系，我们知之甚少。我们使用磁共振波谱法测量了20名自闭症儿童和16名发育正常的对照儿童（7至18岁）尾状核、壳核和丘脑的N-乙酰天门冬氨酸、胆碱、肌酸、肌醇和谷氨酸。相对于对照组，自闭症个体壳核中的谷氨酸/肌酸升高。此外，两组在该区域的谷氨酸均随年龄增加。男孩相对于女孩，丘脑的胆碱/肌酸增加。最后，在所有三个区域中，谷氨酸、胆碱和肌醇与自闭症谱系障碍（ASD）组的行为评分之间存在相关性。这些发现表明深部灰质神经化学发生了变化，这些变化对诊断、年龄和性别敏感，并与行为差异相关。
