Fukazawa Kyota, Lee H Thomas
Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, NY, USA.
J Anesth Clin Res. 2013 Sep 27;4(9):352. doi: 10.4172/2155-6148.1000352.
Hepato-renal syndrome (HRS) is one of the most detrimental conditions in patients with end stage liver failure. Historically, HRS was considered a terminal disease associated with cirrhosis and was termed "liver-death syndrome". Furthermore, despite the improved understanding of pathophysiology and the reversibility of renal dysfunction in HRS, mortality remains extremely high especially for type 1 HRS. This review summarizes the recent advances in the pathophysiology, diagnosis and management of HRS and also provides an evolving area of research in the pathophysiologic mechanisms of HRS, which may open the door for new therapeutic approaches.
肝肾综合征（HRS）是终末期肝衰竭患者最严重的病症之一。从历史上看，HRS被认为是一种与肝硬化相关的终末期疾病，被称为“肝死亡综合征”。此外，尽管对HRS的病理生理学和肾功能障碍的可逆性有了更好的理解，但死亡率仍然极高，尤其是1型HRS。本综述总结了HRS在病理生理学、诊断和管理方面的最新进展，并提供了HRS病理生理机制中一个不断发展的研究领域，这可能为新的治疗方法打开大门。
