Amin Amit Dipak, Vishnoi Nidhi, Prochasson Philippe
Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):264-276. doi: 10.1016/j.bbagrm.2011.07.008.
Due to its extensive length, DNA is packaged into a protective chromatin structure known as the nucleosome. In order to carry out various cellular functions, nucleosomes must be disassembled, allowing access to the underlying DNA, and subsequently reassembled on completion of these processes. The assembly and disassembly of nucleosomes is dependent on the function of histone modifiers, chromatin remodelers and histone chaperones. In this review, we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR/HIRA complex. In S. cerevisiae, the HIR complex is made up of the proteins Hir1, Hir2, Hir3 and Hpc2, which collectively act in transcriptional regulation, elongation, gene silencing, cellular senescence and even aging. This review presents an overview of the role of the HIR complex, in yeast as well as other organisms, in each of these processes, in order to give a better understanding of how nucleosome assembly is imperative for cellular homeostasis and genomic integrity. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
由于DNA长度很长，它被包装成一种名为核小体的保护性染色质结构。为了执行各种细胞功能，核小体必须被拆解，以便能够接触到其下的DNA，然后在这些过程完成后重新组装。核小体的组装和拆解取决于组蛋白修饰因子、染色质重塑因子和组蛋白伴侣的功能。在这篇综述中，我们讨论一种名为HIR/HIRA复合物的进化保守型组蛋白伴侣的作用。在酿酒酵母中，HIR复合物由Hir1、Hir2、Hir3和Hpc2蛋白组成，它们共同作用于转录调控、延伸、基因沉默、细胞衰老甚至老化过程。这篇综述概述了HIR复合物在酵母以及其他生物体中在上述每个过程中的作用，以便更好地理解核小体组装对于细胞稳态和基因组完整性的重要性。本文是名为：组蛋白伴侣与染色质组装的特刊的一部分。
