[甲胎蛋白（AFP）分泌性肿瘤的一般概念，特别涉及组织发生]
[General concepts of alpha-fetoprotein (AFP)-secreting tumors, with special reference to the histogenesis].
作者信息
Okamoto T
机构信息
Dept. of Pathology, Fukuyama National Hospital.
出版信息
Gan No Rinsho. 1987 Oct;33(12):1397-401.
Recently, in addition to yolk sac tumors (YST) and hepatocellular carcinomas, many AFP-secreting tumors have been reported. A comparative morphological study of YST to the human yolk sac has revealed tumor cells mimicking the behavior of the human yolk sac endodermal cells (HYSEC). Another investigation suggests that an embryonal carcinoma (adult type), a gastric adenocarcinoma, or an ovarian adenocarcinoma, each showing no histologic features specific for YST, have a selective differentiation to HYSEC which can secrete an increased serum AFP. These tumors might well be called endodermal cell tumors. The histogenesis of AFP-secreting tumors can be attributed to the endodermal origin (or retrodifferentiation to the HYSEC).
最近，除了卵黄囊瘤（YST）和肝细胞癌外，还报道了许多分泌甲胎蛋白（AFP）的肿瘤。一项对YST与人类卵黄囊的比较形态学研究显示，肿瘤细胞模仿了人类卵黄囊内胚层细胞（HYSEC）的行为。另一项研究表明，胚胎癌（成人型）、胃腺癌或卵巢腺癌，每一种都没有YST特有的组织学特征，但都有向HYSEC选择性分化的能力，而HYSEC可分泌升高的血清AFP。这些肿瘤很可能可称为内胚层细胞瘤。分泌AFP肿瘤的组织发生可归因于内胚层起源（或向HYSEC的逆分化）。
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