Okamoto T, Hirabayashi K, Ishiguro T
Department of Pathology, Fukuyama National Hospital.
Jpn J Cancer Res. 1993 Apr;84(4):360-4. doi: 10.1111/j.1349-7006.1993.tb00144.x.
In order to clarify the histogenesis of alpha-fetoprotein (AFP)-secreting tumor tissues, formalin-fixed, paraffin-embedded serial sections of 148 tumors in various organs were examined by the peroxidase-antiperoxidase method for AFP, and paradoxical concanavalin A staining. Yolk sac-type AFP was found in yolk sac tumors, embryonal carcinomas, solid teratomas, (yolk sac) endodermal cell tumors, adenocarcinomas (stomach, ovary or lung) and metastatic liver cancers. Hepatic-type AFP was demonstrated in hepatocellular carcinomas, hepatoblastomas, solid teratomas and a stomach cancer. Yolk sac-type AFP was observed in the neighboring liver cells of metastatic liver cancers without relation to the type of AFP in primary cancers. The results from serum analyses of preoperative tumor-bearing patients (68 cases) were coincident with those from immunohistochemical stainings.
为阐明分泌甲胎蛋白（AFP）肿瘤组织的组织发生，采用过氧化物酶抗过氧化物酶法检测AFP及伴刀豆球蛋白A染色，对148例各器官肿瘤的福尔马林固定、石蜡包埋连续切片进行了检查。在卵黄囊瘤、胚胎癌、实性畸胎瘤、（卵黄囊）内胚层细胞瘤、腺癌（胃、卵巢或肺）及转移性肝癌中发现卵黄囊型AFP。在肝细胞癌、肝母细胞瘤、实性畸胎瘤及1例胃癌中证实有肝型AFP。在转移性肝癌的邻近肝细胞中观察到卵黄囊型AFP，与原发癌的AFP类型无关。术前荷瘤患者（68例）血清分析结果与免疫组织化学染色结果相符。
