College of Medicine, Mayo Medical School, Rochester, Minnesota.
Dermatol Surg. 2014 Mar;40(3):241-6. doi: 10.1111/dsu.12433. Epub 2014 Jan 25.
Sebaceous carcinoma (SC) is a rare cutaneous neoplasm.
To characterize SC and treatment approaches and outcomes.
We retrospectively reviewed records of patients with SC from 1992 through 2012. Recurrence-free survival was estimated and compared between groups.
We identified 52 patients with SC (39, 75.0% male). Mean age ± standard deviation at diagnosis was 72.7 ± 10.8. Forty-nine patients (94.2%) were white. Twenty-one (of 29 with known status) had a diagnosis of Muir-Torre syndrome. Six had multiple primary SCs (total of 73 SCs in 52 patients). The most common locations for SC were the back (20.5%), cheek (13.7%), nose (11.0%), and eye (9.6%). Treatment was recorded for 70 SCs; 35 (50.0%) were treated using Mohs micrographic surgery (MMS) and 26 (37.1%) using wide local excision (WLE). Of the 45 patients (66 SCs) with clinical follow-up, three (6.7% of patients; 4.8% of SCs) had documented recurrence.
MMS and WLE are effective treatments for SC. Further research is warranted to determine whether one treatment is more efficacious than the other.
皮脂腺癌（SC）是一种罕见的皮肤肿瘤。
描述 SC 的特征、治疗方法和结局。
我们回顾性地分析了 1992 年至 2012 年期间患有 SC 的患者的记录。估计并比较了各组之间的无复发生存率。
我们确定了 52 例 SC 患者（39 例，75.0%为男性）。诊断时的平均年龄±标准差为 72.7±10.8 岁。49 例（已知 29 例）为白人。21 例（29 例已知诊断的患者中有 21 例）患有 Muir-Torre 综合征。6 例患有多发性原发性 SC（52 例患者共有 73 例 SC）。SC 最常见的部位是背部（20.5%）、脸颊（13.7%）、鼻子（11.0%）和眼睛（9.6%）。记录了 70 例 SC 的治疗情况；35 例（50.0%）采用 Mohs 显微外科手术（MMS）治疗，26 例（37.1%）采用广泛局部切除术（WLE）治疗。在 45 例（66 例 SC）有临床随访的患者中，有 3 例（6.7%的患者；4.8%的 SC）有记录的复发。
MMS 和 WLE 是治疗 SC 的有效方法。需要进一步研究以确定哪种治疗方法更有效。
