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一名72岁患者右拇指远节指骨处罕见的皮肤恶性附属器肿瘤合并原发性肺癌:病例报告

Rare malignant adnexal tumour of the skin involving distal phalanx of right thumb with co-existing primary lung cancer in a 72-year-old patient: A case report.

作者信息

Aggarwal Deepika, Jain Vimal

机构信息

Department of General Surgery, Mata Chanan Devi Hospital, New Delhi, India.

Department of General Surgery, Mata Chanan Devi Hospital, New Delhi, India.

出版信息

Int J Surg Case Rep. 2022 Jun;95:107174. doi: 10.1016/j.ijscr.2022.107174. Epub 2022 May 10.

DOI:10.1016/j.ijscr.2022.107174
PMID:35569312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9112114/
Abstract

INTRODUCTION AND IMPORTANCE

Malignant adnexal tumours of the skin are a group of rare malignancies. These tumours can further differentiate into eccrine, apocrine, sebaceous, sweat duct, or ceruminous glands within the skin or follicular cells. Sebaceous carcinoma, a malignant adnexal tumour of the skin, is a rare and malignant tumour of the sebaceous glands. They can occur anywhere in the body where sebaceous glands are present, the most common being the head and neck region.

CASE REPORT

Here we report a case of a 72-year-old man who presented with a bleeding ulcer on the distal right thumb, which was progressively increasing in size. Biopsy and histology confirmed the diagnosis of MATS with sebaceous differentiation. He had been diagnosed with metastatic non-small cell lung carcinoma six months back.

CLINICAL DISCUSSION AND CONCLUSION

SC is a rare and unusual tumour amounting to less than 1% of all cutaneous malignancies. Phalanges are an infrequent extra-ocular site of involvement, and initial presentation can be mistaken for a benign occurrence. Any patient presenting with extra-ocular SC is advised to undergo genetic and immunohistochemistry testing to rule out complex genetic syndromes like Muir Torre syndrome and Cowden syndrome.

摘要

引言与重要性

皮肤恶性附件肿瘤是一组罕见的恶性肿瘤。这些肿瘤可进一步分化为皮肤内的小汗腺、大汗腺、皮脂腺、汗腺导管或耵聍腺或毛囊细胞。皮脂腺癌是一种皮肤恶性附件肿瘤,是皮脂腺的一种罕见恶性肿瘤。它们可发生于身体任何有皮脂腺的部位,最常见于头颈部区域。

病例报告

在此我们报告一例72岁男性患者,其右拇指远端出现一个出血性溃疡,且溃疡大小逐渐增大。活检及组织学检查确诊为具有皮脂腺分化的皮肤恶性附属器肿瘤。他在六个月前被诊断为转移性非小细胞肺癌。

临床讨论与结论

皮脂腺癌是一种罕见且不常见的肿瘤,占所有皮肤恶性肿瘤的比例不到1%。指骨是眼外较少见的受累部位,最初表现可能被误诊为良性病变。建议任何出现眼外皮脂腺癌的患者接受基因和免疫组织化学检测,以排除像穆尔 - 托里综合征和考登综合征等复杂的遗传综合征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/34bcbec18f19/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/6b5d9336e8f9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/1ca385d32385/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/b5102ccf72d8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/86f9f009d018/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/dbfeaec59b6f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/34bcbec18f19/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/6b5d9336e8f9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/1ca385d32385/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/b5102ccf72d8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/86f9f009d018/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/dbfeaec59b6f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b5c/9112114/34bcbec18f19/gr6.jpg

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