College of Medicine, Seoul National University, Seoul National University Bundang Hospital, Gyeonggi, Korea.
Dermatol Surg. 2014 Apr;40(4):405-11. doi: 10.1111/dsu.12451. Epub 2014 Jan 25.
Despite several recent reports on the efficacy of long-pulse pulsed dye laser (LP-PDL) in treating infantile hemangiomas, controversy remains.
To determine the beneficial effects of early therapeutic intervention with LP-PDL in superficial and mixed hemangiomas.
Clinical data from 40 children with 47 hemangiomas in preproliferative or proliferative phase treated with LP-PDL in a Korean tertiary hospital over 5 years were analyzed retrospectively. Treatments were repeated at 1- to 4-week intervals until growth stopped.
Of the 47 hemangiomas, 32 were superficial, and 15 were mixed at presentation. Age was 9.6 ± 5.9 weeks at initiation of treatment and 18.0 ± 8.6 weeks at completion, and a positive linear correlation existed between the two. There were a mean of 4.6 ± 2.6 treatments per hemangioma, which was lower in superficial than in mixed hemangiomas. Improvement in color was documented in 84.4% of superficial and 86.7% of mixed hemangiomas, and 75.0% of superficial and 66.7% of mixed shrank. Hyperpigmentation occurred in two superficial hemangiomas.
Early intervention in hemangiomas using LP-PDL successfully prevents further growth and accelerates a transition to plateau or involution phase with minimal adverse events, achieving good cosmetic outcomes.
尽管最近有几篇关于长脉冲脉冲染料激光（LP-PDL）治疗婴儿血管瘤疗效的报道，但仍存在争议。
确定 LP-PDL 早期治疗干预对表浅型和混合性血管瘤的有益效果。
回顾性分析了 5 年来在韩国一家三级医院接受 LP-PDL 治疗的 40 例处于增殖前期或增殖期的 47 例血管瘤患儿的临床资料。治疗间隔为 1-4 周，直至生长停止。
47 个血管瘤中，32 个为表浅型，15 个为混合性。治疗开始时的年龄为 9.6±5.9 周，完成时为 18.0±8.6 周，两者呈正线性相关。每个血管瘤的平均治疗次数为 4.6±2.6 次，表浅型血管瘤的治疗次数少于混合性血管瘤。84.4%的表浅型血管瘤和 86.7%的混合性血管瘤颜色改善，75.0%的表浅型血管瘤和 66.7%的混合性血管瘤缩小。2 例表浅型血管瘤出现色素沉着过度。
使用 LP-PDL 对血管瘤进行早期干预可成功阻止其进一步生长，并加速向平台期或消退期过渡，同时不良反应最小，获得良好的美容效果。
