McClure M O, Sattentau Q J, Beverley P C, Hearn J P, Fitzgerald A K, Zuckerman A J, Weiss R A
Chester Beatty Laboratories, Institute of Cancer Research, London, UK.
Nature. 1987;330(6147):487-9. doi: 10.1038/330487a0.
The CD4 T-lymphocyte differentiation antigen is an essential component of the cell surface receptor for human immunodeficiency viruses (HIVs) causing AIDS (acquired immune deficiency syndrome) (refs 1-3). Peripheral blood lymphocytes of apes, New World and Old World monkeys express cell surface antigens homologous to CD4 of human T-helper lymphocytes. The cells of several of these species can be infected in short term culture with diverse strains of the type-1 or type-2 human immunodeficiency viruses (HIV-1 and HIV-2). HIV-1 is the prototype AIDS virus, and HIV-2 is the second type of AIDS virus, prevalent in West Africa. Infection of the primate cells correlates with evolutionary conservation on CD4 of one particular epitope cluster, and is inhibited by treatment of the cells with monoclonal antibodies to this epitope. The capacity of HIV to replicate in simian cells may provide a means for evaluating antiviral drugs and vaccines.
CD4 T淋巴细胞分化抗原是导致获得性免疫缺陷综合征（AIDS，艾滋病）的人类免疫缺陷病毒（HIV）细胞表面受体的重要组成部分（参考文献1 - 3）。猿类、新大陆猴和旧大陆猴的外周血淋巴细胞表达与人T辅助淋巴细胞CD4同源的细胞表面抗原。这些物种中的几种细胞在短期培养中可被1型或2型人类免疫缺陷病毒（HIV - 1和HIV - 2）的不同毒株感染。HIV - 1是典型的艾滋病病毒，HIV - 2是第二种艾滋病病毒，在西非流行。灵长类细胞的感染与一个特定表位簇在CD4上的进化保守性相关，并且用针对该表位的单克隆抗体处理细胞可抑制感染。HIV在猿猴细胞中复制的能力可能为评估抗病毒药物和疫苗提供一种手段。
