Sakamoto N, Michel J P, Kopp N, Tohyama M, Pearson J
Department of Anatomy, Osaka University Medical School, Japan.
Neuroscience. 1987 Sep;22(3):801-11. doi: 10.1016/0306-4522(87)92960-5.
Neurons strongly immunoreactive for substance P are present as subpopulations in the stratum oriens, pyramidal layer and polymorphic layer of the hippocampus of the human infant. Substance P immunoreactive terminals are numerous on other neuronal cell bodies in the polymorphic layer and over pyramidal cells of the subiculum and the CA1, 2 and 3 regions. There is a high density of substance P-immunoreactive axons in the granular layer. Enkephalin immunoreactive neurons are relatively few in number and are present in the polymorphic and pyramidal layers. The results indicate that substance P probably plays a major role in short range circuits in the human hippocampus and that intrinsic enkephalin neurons probably play a relatively minor role.
对P物质呈强免疫反应的神经元，作为亚群存在于人类婴儿海马的腔隙层、锥体细胞层和多形层。P物质免疫反应终末在多形层的其他神经元胞体上以及海马下脚和CA1、CA2及CA3区的锥体细胞上大量存在。颗粒层中有高密度的P物质免疫反应性轴突。脑啡肽免疫反应性神经元数量相对较少，存在于多形层和锥体细胞层。结果表明，P物质可能在人类海马的短程回路中起主要作用，而内源性脑啡肽神经元可能起相对较小的作用。
