Lindahl Ulf
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, SE-751 23 Uppsala, Sweden.
Matrix Biol. 2014 Apr;35:3-7. doi: 10.1016/j.matbio.2014.01.001. Epub 2014 Jan 23.
The concept of "proteoglycans" as discrete molecules surfaced some 40 years ago, out of previously muddled notions of the extracellular matrix. Core proteins were gradually recognized as molecular entities, distinct with regard to location, substitution with glycosaminoglycan (GAG) chains and biological function. This development is surveyed, with brief outline of methodological approaches, biosynthesis, and functional aspects. Special emphasis is given to the impact of genomics on the field. Some outstanding unresolved issues are emphasized, including regulation of GAG biosynthesis and the specificity of GAG-protein interactions.
“蛋白聚糖”作为离散分子的概念大约在40年前出现，源于此前对细胞外基质的模糊认识。核心蛋白逐渐被视为分子实体，在位置、被糖胺聚糖（GAG）链取代的情况以及生物学功能方面都有所不同。本文综述了这一发展过程，并简要概述了方法学、生物合成及功能方面的内容。特别强调了基因组学对该领域的影响。文中还强调了一些尚未解决的突出问题，包括GAG生物合成的调控以及GAG - 蛋白相互作用的特异性。
