磁共振引导高强度聚焦超声用于图像引导的温度诱导药物输送。
Magnetic resonance guided high-intensity focused ultrasound for image-guided temperature-induced drug delivery.
机构信息
Eindhoven University of Technology, Dept. of Biomedical NMR, Eindhoven, The Netherlands; Center for Imaging Research and Education (CIRE), Eindhoven, The Netherlands.
Philips Research Eindhoven, Minimally Invasive Healthcare, Eindhoven, The Netherlands; Center for Imaging Research and Education (CIRE), Eindhoven, The Netherlands.
出版信息
Adv Drug Deliv Rev. 2014 Jun;72:65-81. doi: 10.1016/j.addr.2014.01.006. Epub 2014 Jan 22.
Magnetic resonance guided high-intensity focused ultrasound (MR-HIFU) is a versatile technology platform for noninvasive thermal therapies in oncology. Since MR-HIFU allows heating of deep-seated tissue to well-defined temperatures under MR image guidance, this novel technology has great potential for local heat-mediated drug delivery from temperature-sensitive liposomes (TSLs). In particular, MR provides the ability for image guidance of the drug delivery when an MRI contrast agent is co-encapsulated with the drug in the aqueous lumen of the liposomes. Monitoring of the tumor drug coverage offers possibilities for a personalized thermal treatment in oncology. This review focuses on MR-HIFU as a noninvasive technology platform, temperature-sensitive liposomal formulations for drug delivery and image-guided drug delivery, and the effect of HIFU-induced hyperthermia on the TSL and drug distribution. Finally, the opportunities and challenges of localized MR-HIFU-mediated drug delivery from temperature-sensitive liposomes in oncology are discussed.
磁共振引导高强度聚焦超声（MR-HIFU）是一种多功能技术平台，可用于肿瘤学的非侵入性热疗。由于 MR-HIFU 允许在磁共振图像引导下将深部组织加热到明确的温度，因此这项新技术在从热敏脂质体（TSL）进行局部热介导药物输送方面具有巨大的潜力。特别是，当将 MRI 造影剂与脂质体水腔中的药物共包封时，MR 提供了在药物输送时进行图像引导的能力。监测肿瘤药物覆盖范围为肿瘤学中的个性化热疗提供了可能性。这篇综述重点介绍了作为一种非侵入性技术平台的 MR-HIFU、用于药物输送和图像引导药物输送的热敏脂质体制剂，以及 HIFU 诱导的热疗对 TSL 和药物分布的影响。最后，讨论了局部性 MR-HIFU 介导的热敏脂质体在肿瘤学中的药物输送的机会和挑战。
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