Yin Jun, Wang Liming, Shi Yijun, Shao Aizhong, Tang Weifeng, Wang Xu, Zhang Wenbo, Ding Guowen, Liu Chao, Chen Yijang, Chen Suocheng, Gu Haiyong
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212002, China.
Mol Biol Rep. 2014;41(4):1951-7. doi: 10.1007/s11033-014-3042-8. Epub 2014 Jan 28.
Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Esophageal cancer is very aggressive; genetic polymorphisms may explain in part the individual differences in esophageal cancer susceptibility. We conducted a hospital based case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs) in the interleukin (IL)-15 and IL-15 receptor alpha (IL-15RA) gene on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a custom-by-design 48-Plex SNPscan(TM) kit. The IL-15RA rs2228059 A>C polymorphism was associated with a decreased risk of ESCC in a recessive genetic model; However, there was no significant association between the other five SNPs and ESCC risk. Stratified analyses indicated a significantly decreased risk of ESCC associated with the IL-15RA rs2228059 A>C polymorphism was evident among male, older, non-smoker, and non-drinker patients. These findings indicated that the functional polymorphism, IL-15RA rs2228059 A>C, might contribute to ESCC susceptibility. However, the statistical power of our study was limited because of the moderate sample size and absence of a validation cohort. Large well-designed studies are warranted to confirm our findings.
食管癌是全球第六大癌症相关死亡原因。食管癌侵袭性很强；基因多态性可能部分解释了食管癌易感性的个体差异。我们开展了一项基于医院的病例对照研究，以评估白细胞介素（IL）-15和IL-15受体α（IL-15RA）基因中功能性单核苷酸多态性（SNP）对食管癌发生的遗传影响。本研究共纳入380例食管鳞状细胞癌（ESCC）病例和380例对照。使用定制的48重SNPscan™试剂盒确定基因型。在隐性遗传模型中，IL-15RA rs2228059 A>C多态性与ESCC风险降低相关；然而，其他五个SNP与ESCC风险之间无显著关联。分层分析表明，在男性、老年、不吸烟和不饮酒患者中，与IL-15RA rs2228059 A>C多态性相关的ESCC风险显著降低。这些发现表明，功能性多态性IL-15RA rs2228059 A>C可能与ESCC易感性有关。然而，由于样本量适中且缺乏验证队列，我们研究的统计效力有限。需要开展大规模精心设计的研究来证实我们的发现。
