Surface ultrastructure of cultures of affected psoriatic keratinocytes, unaffected psoriatic keratinocytes and normal keratinocytes.

The surface structure of 11-12 days old cultures from biopsies of normal skin and uninvolved psoriatic skin was investigated by scanning electron microscopy. The keratinocytes formed flat, thin, and well-organized layers of elongated, tightly apposed cells. Newly-formed cells with few and short microplicae and microvilli were seen at the colony periphery. On the maturing cells towards the colony center, the number and size of microplicae or microvilli increased gradually. No differences were found between the structures on normal keratinocytes and keratinocytes from uninvolved psoriatic skin, but in keratinocytes from involved psoriatic skin glomerulus-like rolled microplicae occasionally were found.