Carreón Tania, Hein Misty J, Hanley Kevin W, Viet Susan M, Ruder Avima M
Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
Am J Ind Med. 2014 Apr;57(4):398-411. doi: 10.1002/ajim.22299. Epub 2014 Jan 24.
We updated through 2007 the mortality experience of 1,874 workers employed at a New York State chemical manufacturing plant between 1946 and 2006.
Reassessed exposures to vinyl chloride, carbon disulfide, and shift work and categories of o-toluidine exposure were based on year, department and job title. Standardized mortality ratios (SMR) compared mortality to that of the US population. Internal comparisons used directly standardized rate ratios.
Hepatobiliary cancer mortality was elevated among workers ever exposed to vinyl chloride (SMR = 3.80, 95% confidence interval 1.89-6.80); directly standardized rates increased with increasing vinyl chloride exposure duration. No increase in non-Hodgkin lymphoma mortality was observed with vinyl chloride and shift work exposures. Internal comparisons showed increased coronary artery disease mortality among long-term workers exposed to carbon disulfide and shift work for 4 years or more.
Excess coronary artery disease mortality confirms earlier results; further investigation is needed to understand risk factors.
我们更新了1946年至2006年间在纽约州一家化学制造工厂工作的1874名工人截至2007年的死亡情况。
根据年份、部门和职位重新评估氯乙烯、二硫化碳的暴露情况以及轮班工作和邻甲苯胺暴露类别。标准化死亡比（SMR）将死亡率与美国人群的死亡率进行比较。内部比较使用直接标准化率比。
曾接触氯乙烯的工人中肝胆癌死亡率升高（SMR = 3.80，95%置信区间1.89 - 6.80）；直接标准化率随氯乙烯暴露持续时间的增加而升高。未观察到氯乙烯和轮班工作暴露导致非霍奇金淋巴瘤死亡率增加。内部比较显示，长期接触二硫化碳和轮班工作4年或更长时间的工人中冠状动脉疾病死亡率增加。
冠状动脉疾病死亡率过高证实了早期结果；需要进一步调查以了解风险因素。
