Shi Yun, Sun Min, Wang Zhixiao, Fu Qi, Cao Mengdie, Zhu Zhenxin, Meng Chuchen, Mao Jia, Duan Yu, Tang Wei, Huang Xiaoping, Lu Jieli, Bi Yufang, Ning Guang, He Wei, Yang Tao
Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Endocrine. 2014 Sep;47(1):227-33. doi: 10.1007/s12020-013-0147-0. Epub 2014 Jan 24.
Although it is generally accepted that thyroid hormones affect bone metabolism, there is little data on the association of thyroid antibodies with bone status. We aimed to investigate the association between thyroid hormones or antibodies and quantitative ultrasound (QUS) parameters. This was a cross-sectional, population-based study conducted in Nanjing, China. A total of 1,001 Chinese men over 40 years were enrolled. We measured free triiodothyronine, free thyroxin (fT4), thyroid-stimulating hormone, anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin, 25-hydroxyvitamin D, and QUS parameters. After adjusting for potential confounders, QUS values decreased from the lowest to highest tertiles of fT4 in euthyroid men [quantitative ultrasound index (QUI) p = 0.002, broadband ultrasound attenuation (BUA) p = 0.000, speed of sound (SOS) p = 0.009, respectively]. Men with high anti-TPO levels (≥200 IU/ml) were found to have lower QUI (p = 0.030), BUA (p = 0.034), and SOS (p = 0.041) values than controls (<200 IU/ml). The prevalence of vitamin D deficiency was significantly higher in individuals with high anti-TPO than those in lower levels (87.5 vs. 59.5 %, p = 0.001). Our results suggest that high fT4 or anti-TPO values are associated with lower QUS parameters. Prospective studies are needed to confirm the precise relationship between thyroid status and osteoporosis.
尽管甲状腺激素影响骨代谢这一观点已被广泛接受，但关于甲状腺抗体与骨状态之间关联的数据却很少。我们旨在研究甲状腺激素或抗体与定量超声（QUS）参数之间的关联。这是一项在中国南京开展的基于人群的横断面研究。共纳入了1001名40岁以上的中国男性。我们测量了游离三碘甲状腺原氨酸、游离甲状腺素（fT4）、促甲状腺激素、抗甲状腺过氧化物酶（抗-TPO）、抗甲状腺球蛋白、25-羟维生素D以及QUS参数。在对潜在混杂因素进行校正后，甲状腺功能正常男性的QUS值随着fT4从最低三分位数到最高三分位数而降低[定量超声指数（QUI）p = 0.002，宽带超声衰减（BUA）p = 0.000，声速（SOS）p = 0.009]。抗-TPO水平高（≥200 IU/ml）的男性的QUI（p = 0.030）、BUA（p = 0.034）和SOS（p = 0.041）值低于对照组（<200 IU/ml）。抗-TPO水平高的个体维生素D缺乏的患病率显著高于水平较低者（87.5%对59.5%，p = 0.001）。我们的结果表明，高fT4或抗-TPO值与较低的QUS参数相关。需要进行前瞻性研究以证实甲状腺状态与骨质疏松症之间的确切关系。
