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1
Serum vitamin D levels are decreased in patients without remission of Graves' disease.未缓解的格雷夫斯病患者血清维生素D水平降低。
Endocrine. 2013 Feb;43(1):230-2. doi: 10.1007/s12020-012-9789-6. Epub 2012 Sep 15.
2
High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease.日本女性格雷夫斯病患者维生素D缺乏的高患病率。
Endocr J. 2001 Feb;48(1):63-9. doi: 10.1507/endocrj.48.63.
3
Assays for thyroid-stimulating antibodies and thyrotropin-binding inhibitory immunoglobulins in children with Graves' disease.格雷夫斯病患儿促甲状腺素刺激抗体和促甲状腺素结合抑制性免疫球蛋白检测
Endocr J. 2005 Oct;52(5):505-10. doi: 10.1507/endocrj.52.505.
4
A TSHR-LH/CGR chimera that measures functional thyroid-stimulating autoantibodies (TSAb) can predict remission or recurrence in Graves' patients undergoing antithyroid drug (ATD) treatment.一种 TSHR-LH/CGR 嵌合体，可测量功能型甲状腺刺激自身抗体（TSAb），可预测 Graves 病患者接受抗甲状腺药物（ATD）治疗后的缓解或复发。
J Clin Endocrinol Metab. 2012 Jul;97(7):E1080-7. doi: 10.1210/jc.2011-2897. Epub 2012 Apr 6.
5
Prognostic value of thyrotropin receptor antibodies (TRAb) in Graves' disease: a 120 months prospective study.促甲状腺素受体抗体（TRAb）在Graves病中的预后价值：一项为期120个月的前瞻性研究。
Endocr J. 2007 Dec;54(5):713-20. doi: 10.1507/endocrj.k06-069. Epub 2007 Aug 3.
6
Remission of Graves' hyperthyroidism predicted by smooth decreases of thyroid-stimulating antibody and thyrotropin-binding inhibitor immunoglobulin during antithyroid drug treatment.抗甲状腺药物治疗期间，促甲状腺素抗体和促甲状腺素结合抑制免疫球蛋白水平平稳下降可预测格雷夫斯甲亢的缓解。
Thyroid. 2000 Oct;10(10):891-6. doi: 10.1089/thy.2000.10.891.
7
Vitamin D deficiency in patients with Graves' disease: probably something more than a casual association.格雷夫斯病患者的维生素D缺乏：可能不仅仅是一种偶然关联。
Endocrine. 2013 Feb;43(1):3-5. doi: 10.1007/s12020-012-9776-y. Epub 2012 Aug 25.
8
Response to TRH, serum thyroid hormone concentration, and serum markers of autoimmunity after antithyroid therapy in Graves' disease.格雷夫斯病抗甲状腺治疗后对促甲状腺激素释放激素的反应、血清甲状腺激素浓度及自身免疫血清标志物
J Endocrinol Invest. 1978 Jan;1(1):9-16. doi: 10.1007/BF03346765.
9
[The prognostic application of thyroid volume determination in patients with Graves' disease].[甲状腺体积测定在格雷夫斯病患者中的预后应用]
Nihon Naibunpi Gakkai Zasshi. 1990 May 20;66(5):543-56. doi: 10.1507/endocrine1927.66.5_543.
10
25-Hydroxyvitamin D serum level in Hashimoto's thyroiditis, but not Graves' disease is relatively deficient.桥本甲状腺炎患者血清25-羟维生素D水平相对缺乏，而格雷夫斯病患者则不然。
Endocr J. 2017 Jun 29;64(6):581-587. doi: 10.1507/endocrj.EJ16-0547. Epub 2017 Apr 11.

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1
Genetic evidence of the causal relationship between serum micronutrients and Graves' disease: A Mendelian randomization and cross-sectional observational study.血清微量营养素与格雷夫斯病因果关系的遗传证据：一项孟德尔随机化和横断面观察性研究。
Asia Pac J Clin Nutr. 2025 Jun;34(3):420-429. doi: 10.6133/apjcn.202506_34(3).0016.
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Effects of vitamin D replacement combined with Graves' disease therapy: a retrospective cohort study.维生素D补充联合格雷夫斯病治疗的效果：一项回顾性队列研究
Turk J Med Sci. 2024 Oct 8;55(1):87-95. doi: 10.55730/1300-0144.5946. eCollection 2025.
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Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease-A Comprehensive Review.维生素 D：在自身免疫性甲状腺疾病和乳糜泻的双重关系中不可或缺的营养物质——全面综述
Nutrients. 2024 Jun 4;16(11):1762. doi: 10.3390/nu16111762.
4
Association between serum vitamin D level and Graves' disease: a systematic review and meta-analysis.血清维生素 D 水平与格雷夫斯病的关系：系统评价和荟萃分析。
Nutr J. 2024 Jun 7;23(1):60. doi: 10.1186/s12937-024-00960-2.
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Increased interleukin-9 and Th9 cells in patients with refractory Graves' disease and interleukin-9 polymorphisms are associated with autoimmune thyroid diseases.在难治性格雷夫斯病患者中，白细胞介素-9 和 Th9 细胞增加，白细胞介素-9 多态性与自身免疫性甲状腺疾病相关。
Front Immunol. 2024 Mar 28;15:1341749. doi: 10.3389/fimmu.2024.1341749. eCollection 2024.
6
Vitamin D Levels in Patients with Active and Remission Graves' Disease.活动性和缓解期格雷夫斯病患者的维生素D水平
Medicines (Basel). 2023 Jul 6;10(7):41. doi: 10.3390/medicines10070041.
7
The Role of Vitamin D in Autoimmune Thyroid Diseases: A Narrative Review.维生素D在自身免疫性甲状腺疾病中的作用：一篇叙述性综述。
J Clin Med. 2023 Feb 11;12(4):1452. doi: 10.3390/jcm12041452.
8
On the Centennial of Vitamin D-Vitamin D, Inflammation, and Autoimmune Thyroiditis: A Web of Links and Implications.维生素 D 诞生一百周年纪念——维生素 D、炎症与自身免疫性甲状腺炎：一个相互关联的网络及其意义。
Nutrients. 2022 Nov 26;14(23):5032. doi: 10.3390/nu14235032.
9
Association Between Vitamin D Deficiency and Autoimmune Thyroid Disorder: A Systematic Review.维生素D缺乏与自身免疫性甲状腺疾病之间的关联：一项系统综述。
Cureus. 2022 Jun 12;14(6):e25869. doi: 10.7759/cureus.25869. eCollection 2022 Jun.
10
Vitamin D Implications and Effect of Supplementation in Endocrine Disorders: Autoimmune Thyroid Disorders (Hashimoto's Disease and Grave's Disease), Diabetes Mellitus and Obesity.维生素 D 的影响及其在内分泌疾病中的补充作用：自身免疫性甲状腺疾病（桥本甲状腺炎和格雷夫斯病）、糖尿病和肥胖。
Medicina (Kaunas). 2022 Jan 27;58(2):194. doi: 10.3390/medicina58020194.

本文引用的文献

1
Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves' disease.初发格雷夫斯病女性患者的血清维生素D水平降低，且与甲状腺体积相关。
Endocrine. 2012 Dec;42(3):739-41. doi: 10.1007/s12020-012-9679-y. Epub 2012 May 1.
2
The chemokine system as a therapeutic target in autoimmune thyroid diseases: a focus on the interferon-γ inducible chemokines and their receptor.作为自身免疫性甲状腺疾病治疗靶点的趋化因子系统：聚焦干扰素-γ诱导的趋化因子及其受体。
Curr Pharm Des. 2011;17(29):3202-16. doi: 10.2174/138161211798157559.
3
Relative vitamin D insufficiency in Hashimoto's thyroiditis.桥本甲状腺炎患者存在相对维生素 D 不足。
Thyroid. 2011 Aug;21(8):891-6. doi: 10.1089/thy.2009.0200. Epub 2011 Jul 13.
4
Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population?在健康人群和病态肥胖人群中，血浆 25(OH)D 是否与脂肪因子、炎症细胞因子和胰岛素抵抗有关？
Endocrine. 2010 Oct;38(2):235-42. doi: 10.1007/s12020-010-9379-4. Epub 2010 Jul 23.
5
Vitamin D: modulator of the immune system.维生素 D：免疫系统的调节剂。
Curr Opin Pharmacol. 2010 Aug;10(4):482-96. doi: 10.1016/j.coph.2010.04.001. Epub 2010 Apr 27.
6
Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization.维生素D缺乏调节促甲状腺激素受体免疫诱导的BALB/c小鼠Graves甲亢。
Endocrinology. 2009 Feb;150(2):1051-60. doi: 10.1210/en.2008-1191. Epub 2008 Oct 16.
7
Vitamin D receptor (VDR) gene polymorphisms and Graves' disease: a meta-analysis.维生素D受体（VDR）基因多态性与格雷夫斯病：一项荟萃分析。
Clin Endocrinol (Oxf). 2009 Jun;70(6):938-45. doi: 10.1111/j.1365-2265.2008.03413.x. Epub 2008 Sep 8.
8
Clinical practice. Graves' disease.临床实践。格雷夫斯病。
N Engl J Med. 2008 Jun 12;358(24):2594-605. doi: 10.1056/NEJMcp0801880.
9
Elocalcitol inhibits inflammatory responses in human thyroid cells and T cells.依洛钙醇抑制人甲状腺细胞和T细胞中的炎症反应。
Endocrinology. 2008 Jul;149(7):3626-34. doi: 10.1210/en.2008-0078. Epub 2008 Mar 27.
10
Vitamin D-binding protein (DBP) gene polymorphism is associated with Graves' disease and the vitamin D status in a Polish population study.在一项波兰人群研究中，维生素D结合蛋白（DBP）基因多态性与格雷夫斯病及维生素D状态相关。
Exp Clin Endocrinol Diabetes. 2006 Jun;114(6):329-35. doi: 10.1055/s-2006-924256.

Serum vitamin D levels are decreased in patients without remission of Graves' disease.

作者信息

Yasuda Tetsuyuki, Okamoto Yasuyuki, Hamada Noboru, Miyashita Kazuyuki, Takahara Mitsuyoshi, Sakamoto Fumie, Miyatsuka Takeshi, Kitamura Tetsuhiro, Katakami Naoto, Kawamori Dan, Otsuki Michio, Matsuoka Taka-aki, Kaneto Hideaki, Shimomura Iichiro

机构信息

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

出版信息

Endocrine. 2013 Feb;43(1):230-2. doi: 10.1007/s12020-012-9789-6. Epub 2012 Sep 15.

DOI:10.1007/s12020-012-9789-6
PMID:22983830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3536951/
Abstract
摘要