Department of Otolaryngology-Head and Neck Surgery, and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
J Surg Oncol. 2014 May;109(6):616-22. doi: 10.1002/jso.23536. Epub 2014 Jan 24.
Head and neck basaloid squamous cell carcinoma (BSCC) is increasingly recognized as a malignancy with an evolving duel behavior. Our objective was to describe the site-specific presentation and prognosis of head and neck BSCC in comparison to conventional-type squamous cell carcinoma (SCC) using population-based data.
A total of 1,083 BSCC patients and 66,929 conventional-type SCC patients, diagnosed between 2000 and 2008, were identified using the Surveillance, Epidemiology, and End Results database. Clinicopathologic data were compared using χ(2) analysis. Kaplan-Meier analysis was used to estimate site-stratified disease-specific survival (DSS). BSCC's independent effect on DSS was assessed by multivariable regression analysis.
The oropharynx (61.9%) was the most frequent BSCC site; compared to the larynx (33.3%) in conventional-type SCC. More BSCC patients presented with advanced-stage disease (78.4% vs. 60.1%, P < 0.001). On multivariable analysis, DSS was significantly better in the BSCC group when tumors were located in the oropharynx. Conversely, DSS was worse for BSCC patients with laryngeal tumors. DSS was similar among patients with sinonasal, nasopharyngeal, hypopharyngeal, and oral tumors.
BSCC's propensity for advanced-stage presentation was confirmed in this study. However, BSCC appears to carry a paradoxically similar, or better, prognosis compared to conventional-type SCC in most cases.
头颈部基底细胞样鳞状细胞癌（BSCC）日益被认为是一种具有演变双重行为的恶性肿瘤。我们的目的是使用基于人群的数据，描述头颈部 BSCC 与传统型鳞状细胞癌（SCC）相比的特定部位表现和预后。
使用监测、流行病学和最终结果数据库，共鉴定了 1083 例 BSCC 患者和 66929 例传统型 SCC 患者，诊断时间为 2000 年至 2008 年。使用 χ(2)分析比较临床病理数据。Kaplan-Meier 分析用于估计部位分层疾病特异性生存率（DSS）。多变量回归分析评估 BSCC 对 DSS 的独立影响。
BSCC 最常见的部位是口咽（61.9%）；而在传统型 SCC 中，最常见的部位是喉（33.3%）。与传统型 SCC 相比，更多的 BSCC 患者表现为晚期疾病（78.4% vs. 60.1%，P < 0.001）。在多变量分析中，当肿瘤位于口咽时，BSCC 组的 DSS 明显更好。相反，当肿瘤位于喉部时，BSCC 患者的 DSS 更差。BSCC 患者的鼻腔鼻窦、鼻咽、下咽和口腔肿瘤的 DSS 相似。
本研究证实了 BSCC 晚期表现的倾向。然而，在大多数情况下，BSCC 与传统型 SCC 相比，预后相似或更好。
