Fritsch Valerie A, Gerry Daniel R, Lentsch Eric J
Department of Otolaryngology Head and Neck Surgery (V.A.F., E.J.L.), Medical University of South Carolina, Charleston, South Carolina.
Laryngoscope. 2014 Jul;124(7):1573-8. doi: 10.1002/lary.24384. Epub 2014 Apr 29.
OBJECTIVES/HYPOTHESIS: Basaloid squamous cell carcinoma (BSCC) is considered a rare and possibly more aggressive squamous cell carcinoma (SCC) variant. Until now, a series of exclusively oral cavity BSCC patients has not been previously reported. We endeavored to compare BSCC and SCC of the oral cavity, focusing on epidemiologic factors and survival outcomes.
Retrospective analysis of population-based data.
We compared epidemiologic factors, clinicopathologic data, and disease-specific survivals (DSS) between 92 patients with oral cavity BSCC and 15,181 patients with SCC.
High-grade tumors and distant metastases were more common in the BSCC group (P≤0.001). On multivariable analysis controlling for disease stage, BSCC patients had similar DSS to those with typical SCC (P=0.231). Although there was a trend favoring definitive radiotherapy for BSCC, there were no significant differences in treatment approach between BSCC and SCC. The choice of treatment modality (radiation, surgery±radiation) did not reveal a difference in DSS between the two tumor subtypes.
Analysis of the largest oral cavity BSCC series to date demonstrates that BSCC of the oral cavity carries a comparable prognosis to conventional-type oral SCC.
2b.
目的/假设：基底样鳞状细胞癌（BSCC）被认为是一种罕见且可能更具侵袭性的鳞状细胞癌（SCC）变体。到目前为止，此前尚未有一系列仅关于口腔BSCC患者的报道。我们致力于比较口腔BSCC和SCC，重点关注流行病学因素和生存结果。
基于人群数据的回顾性分析。
我们比较了92例口腔BSCC患者和15181例SCC患者的流行病学因素、临床病理数据和疾病特异性生存率（DSS）。
高级别肿瘤和远处转移在BSCC组中更为常见（P≤0.001）。在控制疾病分期的多变量分析中，BSCC患者的DSS与典型SCC患者相似（P = 0.231）。尽管有对BSCC进行根治性放疗的趋势，但BSCC和SCC在治疗方法上没有显著差异。治疗方式（放疗、手术±放疗）的选择在两种肿瘤亚型的DSS上未显示出差异。
对迄今为止最大的口腔BSCC系列的分析表明，口腔BSCC的预后与传统型口腔SCC相当。证据级别：2b。
