Govindarajan S, Fong T L, Ashcavai M
Department of Pathology, University of Southern California, Downey.
Am J Clin Pathol. 1987 Dec;88(6):722-4. doi: 10.1093/ajcp/88.6.722.
Using affinity chromatography on concanavalin A Sepharose, the authors studied the molecular heterogeneity of the serum alpha-fetoprotein of 53 patients with hepatocellular carcinoma, 16 patients with metastatic tumors to the liver, and 16 patients with germ cell tumors. Mean concanavalin binding of alpha-fetoprotein in the sera of patients with hepatocellular carcinoma was 79%, whereas the mean binding in metastatic tumors was 52% and that of germ cell tumors was 45%. This striking molecular variation of the alpha-fetoprotein produced by these different tumors is helpful in the clinical distinction of these tumors.
作者利用伴刀豆球蛋白A琼脂糖亲和层析法，研究了53例肝细胞癌患者、16例肝转移瘤患者和16例生殖细胞肿瘤患者血清甲胎蛋白的分子异质性。肝细胞癌患者血清中甲胎蛋白的伴刀豆球蛋白平均结合率为79%，而转移瘤患者的平均结合率为52%，生殖细胞肿瘤患者的平均结合率为45%。这些不同肿瘤产生的甲胎蛋白这种显著的分子差异，有助于这些肿瘤的临床鉴别。
