Buamah P K, Gibb I, Bates G, Ward A M
Clin Chim Acta. 1984 Jun 13;139(3):313-6. doi: 10.1016/0009-8981(84)90277-8.
The concanavalin A binding characteristics of serum alpha-fetoprotein (AFP) were investigated in patients with primary hepatocellular carcinoma and hepatic secondaries using affinity column chromatography and radioimmunoassay. The primary hepatocellular carcinoma (n = 21) was associated with a median concanavalin A non-reactive AFP fraction of 7.4% (range 1.6 - 18.8) while the hepatic secondaries (n = 8) had a median concanavalin A non-reactive AFP fraction of 50.7% (range 26.6 - 91.7). A simple diagnostic test for differentiating between the two groups of patients is proposed.
利用亲和柱色谱法和放射免疫分析法，对原发性肝细胞癌和肝转移癌患者血清甲胎蛋白（AFP）的伴刀豆球蛋白A结合特性进行了研究。原发性肝细胞癌患者（n = 21）中，伴刀豆球蛋白A无反应性AFP组分的中位数为7.4%（范围1.6 - 18.8），而肝转移癌患者（n = 8）中，伴刀豆球蛋白A无反应性AFP组分的中位数为50.7%（范围26.6 - 91.7）。本文提出了一种区分这两组患者的简易诊断试验。
