Li Chung-Hao, Yang Yi-Ching, Wu Jin-Shang, Huang Ying-Hsiang, Lee Chih-Ting, Lu Feng-Hwa, Chang Chih-Jen
Department of Family Medicine, Tainan Municipal An-Nan Hospital- China Medical University, Taiwan.
Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan ; Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
PLoS One. 2014 Jan 22;9(1):e86022. doi: 10.1371/journal.pone.0086022. eCollection 2014.
Tea has attracted considerable attention for its potential cardioprotective effects. The primary chemical components of tea are thought to have a beneficial effect by reducing arterial stiffness. The objective of this study was to assess the association between tea consumption and brachial-ankle pulse wave velocity (baPWV) in a relatively healthy Chinese population.
We enrolled 3,135 apparently healthy subjects from October 2006 to August 2009. Subjects taking medication for diabetes, hypertension, or hyperlipidemia, or with a history of cardiovascular disease, were excluded from the study. The subjects were categorized into three groups according to their tea-drinking habits: (1) none to low (n = 1615), defined as non-habitual tea drinkers, or drinking for <1 year, or drinking ≤150 mL per day for ≥1 year ; (2) moderate tea consumption, defined as drinking for ≥1 year and consumption between 151 and 450 mL per day; and (3) heavy tea consumption, defined as a drinking for ≥1 year and consumption >450 mL per day. Multiple logistic regression was used to determine whether different levels of consumption were independently associated with the highest quartile of baPWV values, defined as ≥1428.5 cm/s.
Of the 3,135 subjects, 48.5% had drunk >150 mL of tea per day for at least 1 year. In multivariate regression analysis with adjustment for co-variables, including, age, sex, current smoking, alcohol use, habitual exercise, total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) ratio >5, obesity, newly diagnosed hypertension and diabetes, subjects with high tea consumption had a decreased risk of highest quartile of baPWV by 22% (odds ratio = 0.78, 95% confidence interval = 0.62-0.98, p = 0.032), while subjects with moderate tea consumption did not (p = 0.742), as compared subjects with none to low tea consumption.
High, but not moderate, habitual tea consumption may decrease arterial stiffness.
茶因其潜在的心脏保护作用而备受关注。茶的主要化学成分被认为通过降低动脉僵硬度而产生有益作用。本研究的目的是评估在相对健康的中国人群中茶的摄入量与臂踝脉搏波速度（baPWV）之间的关联。
我们在2006年10月至2009年8月期间招募了3135名表面健康的受试者。正在服用糖尿病、高血压或高脂血症药物，或有心血管疾病史的受试者被排除在研究之外。根据受试者的饮茶习惯将其分为三组：（1）无至低饮茶组（n = 1615），定义为非习惯性饮茶者，或饮茶时间<1年，或连续≥1年每天饮茶量≤150 mL；（2）适度饮茶组，定义为饮茶时间≥1年且每天饮茶量在151至450 mL之间；（3）大量饮茶组，定义为饮茶时间≥1年且每天饮茶量>450 mL。采用多因素逻辑回归分析来确定不同饮茶水平是否与baPWV值最高四分位数（定义为≥1428.5 cm/s）独立相关。
在3135名受试者中，48.5%的人每天饮茶量>150 mL至少1年。在对包括年龄、性别、当前吸烟状况、饮酒情况、习惯性运动、总胆固醇/高密度脂蛋白胆固醇（TC/HDL-C）比值>5、肥胖、新诊断的高血压和糖尿病等协变量进行调整的多变量回归分析中，与无至低饮茶组相比，大量饮茶组受试者baPWV值处于最高四分位数的风险降低了22%（比值比=0.78，95%置信区间=0.62 - 0.98，p = 0.032），而适度饮茶组受试者则没有（p = 0.742）。
长期大量饮茶（而非适度饮茶）可能会降低动脉僵硬度。
