Mel'nikova V F, Tsinzerling A V, Aksenov O A, Vydumkina S P, Kalinina N A
Arkh Patol. 1987;49(9):19-25.
Light- and fluorescence-microscopy examinations of 186 placentas were carried out, with concurrent determination of placental interferon, isolation of influenza virus, and serologic tests of maternal and fetal blood, and amniotic fluid. In 32 of the cases, placentitis caused by serotype A or B of influenza virus was present, characterized by hyperplasia and subsequent destruction of amniotic cells, trophoblast, decidual cells, and vascular endothelium, by the presence of influenza antigens, fuchsinophilic cytoplasmic inclusions in the affected cells, and lymphoid infiltrates, and/or by circulatory disturbances. In addition, an interferon possessing properties of viral, immune, and placental interferon was detected in a number of placentas. A or B influenza virus was isolated from 3 placentas. Diagnostic titers of anti-influenza antibody occurred in fetal blood and amniotic fluid samples. The present results indicate that influenza virus may persist and replicate in placental cells.
对186份胎盘进行了光学显微镜和荧光显微镜检查，同时测定胎盘干扰素、分离流感病毒，并对母血、胎儿血和羊水进行血清学检测。32例病例中存在由甲型或乙型流感病毒引起的胎盘炎，其特征为羊膜细胞、滋养层细胞、蜕膜细胞和血管内皮细胞增生并随后遭到破坏，存在流感抗原、受影响细胞中的嗜品红细胞质包涵体以及淋巴细胞浸润，和/或存在循环障碍。此外，在一些胎盘中检测到一种具有病毒干扰素、免疫干扰素和胎盘干扰素特性的干扰素。从3份胎盘中分离出甲型或乙型流感病毒。在胎儿血样和羊水样本中出现了抗流感抗体的诊断效价。目前的结果表明，流感病毒可能在胎盘细胞中持续存在并复制。
