Ornoy A, Dudai M, Sadovsky E
Diagn Gynecol Obstet. 1982 Spring;4(1):11-6.
Placentae and membranes were studied microscopically in five cases of pregnancy interruption due to maternal infectious mononucleosis in the first 2 months of pregnancy. This viral disease, caused by Epstein-Barr virus and apparently rare in pregnancy, induced specific placental lesions. In the decidua, these lesions were manifested by perivasculitis and necrotizing deciduitis. The membranes exhibited slight to moderate chorionitis. In the villi, endovasculitis, perivasculitis, and occasional vascular obliteration were found, as well as mononuclear and plasma cell villitis, with many large atypical vacuolated cells resembling plasma cells. Three fetuses were studied, two of which exhibited myocarditis. The fact that there were placental lesions in all cases studied, and that two of the fetuses exhibited myocarditis, must stimulate further research concerning the possible teratogenicity of this virus in man.
对5例妊娠前2个月因孕妇传染性单核细胞增多症而终止妊娠的胎盘和胎膜进行了显微镜检查。这种由爱泼斯坦-巴尔病毒引起的病毒性疾病在妊娠中显然罕见，可导致特异性胎盘病变。在蜕膜中，这些病变表现为血管周围炎和坏死性蜕膜炎。胎膜表现为轻度至中度绒毛膜炎症。在绒毛中，发现了血管内炎、血管周围炎以及偶见的血管闭塞，还有单核细胞和浆细胞绒毛炎，有许多类似浆细胞的大的非典型空泡化细胞。对3例胎儿进行了研究，其中2例表现为心肌炎。在所研究的所有病例中均存在胎盘病变，且2例胎儿表现为心肌炎，这一事实必然会促使人们进一步研究这种病毒对人类可能的致畸性。
