Sanchez Ana Lourdes, Gabrie José Antonio, Rueda María Mercedes, Mejia Rosa Elena, Bottazzi Maria Elena, Canales Maritza
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
School of Microbiology, National Autonomous University of Honduras (UNAH), Tegucigalpa, Honduras.
PLoS Negl Trop Dis. 2014 Jan 23;8(1):e2653. doi: 10.1371/journal.pntd.0002653. eCollection 2014.
Honduras is endemic for soil-transmitted helminth (STH) infections, but critical information gaps still remain on the prevalence and intensity of these infections as well as on their spatial distribution at subnational levels.
Firstly, to review the research activity on STH infections in Honduras and secondly, to carry out a national prevalence analysis and map the geographical distribution of these infections in children.
A systematic search was conducted of the published and grey literature to identify scientific work on the impact and prevalence of STH infections done between May 1930 and June 30, 2012. International databases and Honduran journals were searched. Grey literature was gleaned from local libraries and key informants. Select studies conducted between 2001 and 2012 were used to produce prevalence maps and to investigate association between STH prevalence and socio-economic and environmental factors.
Of 257 identified studies, 211 (21.4% peer-reviewed) were retained for analysis and categorized as clinical research (10.9%), treatment efficacy studies (8.1%) or epidemiological studies (81%). Prevalence analysis and geographical mapping included 36 epidemiological studies from Honduras's 18 departments and 23% of its municipalities. Overall STH prevalence was >50% in 40.6% of municipalities. Prevalences above 20% for each trichuriasis, ascariasis, and hookworm infection were found in 68%, 47.8%, and 7.2% of studied municipalities, respectively. Municipalities with lower human development index, less access to of potable water, and with higher annual precipitation showed higher STH prevalences.
This is the first study to provide a comprehensive historic review of STH research activity and prevalence in Honduras, revealing important knowledge gaps related to infection risk factors, disease burden, and anti-parasitic drug efficacy, among others. Our decade-long prevalence analysis reveals geographical differences in STH prevalence and these findings suggest that differential intervention strategies might be necessary in Honduras for the control of these infections.
洪都拉斯是土壤传播性蠕虫（STH）感染的流行地区，但在这些感染的患病率、感染强度以及国家以下层面的空间分布方面，关键信息仍存在缺口。
首先，回顾洪都拉斯关于STH感染的研究活动；其次，开展全国患病率分析并绘制儿童中这些感染的地理分布图。
对已发表文献和灰色文献进行系统检索，以确定1930年5月至2012年6月30日期间开展的关于STH感染影响和患病率的科学研究。检索了国际数据库和洪都拉斯期刊。从当地图书馆和关键信息提供者处收集灰色文献。使用2001年至2012年期间开展的部分研究制作患病率地图，并调查STH患病率与社会经济和环境因素之间的关联。
在257项已识别研究中，211项（21.4%为同行评审）被保留用于分析，并分为临床研究（10.9%）、治疗效果研究（8.1%）或流行病学研究（81%）。患病率分析和地理绘图纳入了来自洪都拉斯18个省和23%市镇的36项流行病学研究。40.6%的市镇总体STH患病率>50%。在所研究的市镇中，分别有68%、47.8%和7.2%的市镇鞭虫病、蛔虫病和钩虫感染患病率高于20%。人类发展指数较低、获得安全饮用水机会较少且年降水量较高的市镇STH患病率较高。
这是第一项全面回顾洪都拉斯STH研究活动和患病率的历史性研究，揭示了与感染风险因素、疾病负担和抗寄生虫药物疗效等相关的重要知识缺口。我们长达十年的患病率分析揭示了STH患病率的地理差异，这些发现表明，在洪都拉斯控制这些感染可能需要采取差异化的干预策略。
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