使用下一代纳米颗粒对术前胰导管腺癌患者的淋巴结状态进行准确预测。
Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle.
机构信息
Department of Radiology, Massachusetts General Hospital, Boston, MA ; Center for Systems Biology, Massachusetts General Hospital, Boston, MA.
Department of Surgery, Massachusetts General Hospital, Boston, MA.
出版信息
Transl Oncol. 2013 Dec 1;6(6):670-5. doi: 10.1593/tlo.13400.
OBJECTIVE
The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma.
METHODS
Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign.
RESULTS
A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5% and 98.4% at a nodal level and 83.3% and 80% at a patient level.
CONCLUSION
LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.
目的
本研究旨在评估淋巴靶向纳米颗粒增强磁共振成像（LNMRI）在识别胰腺导管腺癌患者恶性淋巴结受累中的作用。
方法
对 13 例已知或高度怀疑患有胰腺癌且计划行手术切除的患者进行磁共振成像检查。方案包括Ferumoxytol（Feraheme）给药前后的 T2*-加权成像，以评估淋巴结受累情况。13 例患者中有 11 例行胰十二指肠切除术和淋巴结清扫术。无对比摄取的淋巴结被认为是恶性的，而表现出均匀摄取的淋巴结被认为是良性的。
结果
共切除 264 个淋巴结，其中 17 个为恶性。在淋巴结水平上，LNMRI 的灵敏度和特异性分别为 76.5%和 98.4%，在患者水平上分别为 83.3%和 80%。
结论
LNMRI 在胰腺导管腺癌患者中显示出较高的灵敏度和特异性。
Zotero 插件