使用含ferumoxtran-10的亲淋巴纳米颗粒增强磁共振成像对阴茎癌患者进行区域淋巴结分期。
Regional lymph node staging using lymphotropic nanoparticle enhanced magnetic resonance imaging with ferumoxtran-10 in patients with penile cancer.
作者信息
Tabatabaei Shahin, Harisinghani Mukesh, McDougal W Scott
机构信息
Department of Urology, The Massachusetts General Hospital and The Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
J Urol. 2005 Sep;174(3):923-7; discussion 927. doi: 10.1097/01.ju.0000170234.14519.19.
PURPOSE
We evaluated lymphotropic nanoparticle enhanced magnetic resonance imaging (LNMRI) with ferumoxtran-10 in determining the presence of regional lymph node metastases in patients with penile cancer.
MATERIALS AND METHODS
Seven patients with squamous cell carcinoma of the penis underwent LNMRI. All patients subsequently underwent groin dissection and the nodal images were correlated with histology.
RESULTS
We found that LNMRI had sensitivity, specificity, and positive and negative predictive values of 100%, 97%, 81.2% and 100%, respectively, in predicting the presence of regional lymph node metastases in patients with penile cancer.
CONCLUSIONS
Lymph node scanning using LNMRI accurately predicts the pathological status of regional lymph nodes in patients with cancer of the penis. LNMRI may accurately triage patients for regional lymphadenectomy.
目的
我们评估了使用ferumoxtran - 10的亲淋巴纳米颗粒增强磁共振成像（LNMRI）在确定阴茎癌患者区域淋巴结转移情况中的作用。
材料与方法
7例阴茎鳞状细胞癌患者接受了LNMRI检查。所有患者随后均接受了腹股沟淋巴结清扫术，且淋巴结图像与组织学结果进行了对照。
结果
我们发现，在预测阴茎癌患者区域淋巴结转移情况时，LNMRI的敏感性、特异性、阳性预测值和阴性预测值分别为100%、97%、81.2%和100%。
结论
使用LNMRI进行淋巴结扫描可准确预测阴茎癌患者区域淋巴结的病理状态。LNMRI可能有助于准确筛选患者进行区域淋巴结清扫术。
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