Quantitative analysis of rectal cancer by spectral domain optical coherence tomography.

To quantify OCT images of rectal tissue for clinic diagnosis, the scattering coefficient of the tissue is extracted by curve fitting the OCT signals to a confocal single model. A total of 1000 measurements (half and half of normal and malignant tissues) were obtained from 16 recta. The normal rectal tissue has a larger scattering coefficient ranging from 1.09 to 5.41 mm⁻¹ with a mean value of 2.29 mm⁻¹ (std:±0.32), while the malignant group shows lower scattering property and the values ranging from 0.25 to 2.69 mm⁻¹ with a mean value of 1.41 mm⁻¹ (std:±0.18). The peri-cancer of recta has also been investigated to distinguish the difference between normal and malignant rectal tissue. The results demonstrate that the quantitative analysis of the rectal tissue can be used as a promising diagnostic criterion of early rectal cancer, which has great value for clinical medical applications.