Key Laboratory of Optical Information Science and Technology, Institute of Modern Optics, Ministry of Education of China, Nankai University, Tianjin 300071, People's Republic of China.
Phys Med Biol. 2012 Aug 21;57(16):5235-44. doi: 10.1088/0031-9155/57/16/5235. Epub 2012 Jul 31.
To quantify OCT images of rectal tissue for clinic diagnosis, the scattering coefficient of the tissue is extracted by curve fitting the OCT signals to a confocal single model. A total of 1000 measurements (half and half of normal and malignant tissues) were obtained from 16 recta. The normal rectal tissue has a larger scattering coefficient ranging from 1.09 to 5.41 mm⁻¹ with a mean value of 2.29 mm⁻¹ (std:±0.32), while the malignant group shows lower scattering property and the values ranging from 0.25 to 2.69 mm⁻¹ with a mean value of 1.41 mm⁻¹ (std:±0.18). The peri-cancer of recta has also been investigated to distinguish the difference between normal and malignant rectal tissue. The results demonstrate that the quantitative analysis of the rectal tissue can be used as a promising diagnostic criterion of early rectal cancer, which has great value for clinical medical applications.
为了对直肠组织的 OCT 图像进行定量分析以用于临床诊断，通过将 OCT 信号拟合到共焦单模型来提取组织的散射系数。从 16 个直肠中总共获得了 1000 次测量（正常组织和恶性组织各占一半）。正常直肠组织的散射系数较大，范围从 1.09 到 5.41 mm⁻¹，平均值为 2.29 mm⁻¹（标准差：±0.32），而恶性组织的散射系数较低，范围从 0.25 到 2.69 mm⁻¹，平均值为 1.41 mm⁻¹（标准差：±0.18）。还研究了直肠的癌周组织，以区分正常和恶性直肠组织之间的差异。结果表明，直肠组织的定量分析可作为早期直肠癌的有前途的诊断标准，这对临床医疗应用具有重要价值。
