Division of Phytotherapeutics and Metabolic Endocrinology, Faculty of Science, The M.S. University of Baroda, Vadodara-390002, Gujarat, India.
J Sci Food Agric. 2012 Jun;92(8):1688-93. doi: 10.1002/jsfa.5532. Epub 2012 Jan 6.
Oxidative stress induced by reactive oxygen species plays an important role in the aetiology of several diseases including atherosclerosis and coronary heart disease. Anthocyanin-rich extracts have been shown to possess a variety of therapeutic roles, including antioxidant, cardioprotective and hepatoprotective properties. The present inventory was undertaken to evaluate the protective role of anthocyanin-rich red cabbage extract (ARCE) on an atherogenic (ATH) diet-induced hypercholesterolaemia and related cardiac and, hepatic oxidative stress in rats.
ARCE (100 mg kg(-1) body weight) treatment of rats fed the ATH diet significantly prevented elevation in serum and tissue lipids, circulating levels of cardiac and hepatic damage markers, and resulted in excretion of lipids through faeces. Also, the ARCE extract significantly attenuated alterations in the cardiac and hepatic antioxidants and lipid peroxidation, and histopathological changes in cardiac and hepatic tissue.
Thus, the present study provides the first scientific evidence for a protective role of ARCE against ATH diet-induced hypercholesterolaemia and cardiac and hepatic oxidative stress.
活性氧诱导的氧化应激在包括动脉粥样硬化和冠心病在内的几种疾病的发病机制中起着重要作用。富含花色苷的提取物具有多种治疗作用，包括抗氧化、心脏保护和肝脏保护作用。本研究旨在评估富含花色苷的红甘蓝提取物（ARCE）对动脉粥样硬化（ATH）饮食诱导的高胆固醇血症及相关心脏和肝脏氧化应激的保护作用。
ATH 饮食喂养的大鼠用 ARCE（100mg/kg 体重）治疗可显著防止血清和组织脂质升高、循环心脏和肝脏损伤标志物水平升高，并通过粪便排出脂质。此外，ARCE 提取物还显著减轻了心脏和肝脏抗氧化剂和脂质过氧化以及心脏和肝脏组织的组织病理学变化。
因此，本研究首次为 ARCE 对 ATH 饮食诱导的高胆固醇血症及心脏和肝脏氧化应激的保护作用提供了科学依据。
