Jiao Lili, Zhang Xiaoyu, Li Bo, Liu Zhen, Wang Mingzhu, Liu Shuying
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Int J Biol Macromol. 2014 Apr;65:229-33. doi: 10.1016/j.ijbiomac.2014.01.039. Epub 2014 Jan 24.
Water-soluble ginseng oligosaccharides (WGOS) composed of D-glucose with a degree of polymerisation ranging from 2 to 14 were obtained from Panax ginseng C.A. Meyer. In this study, the anti-tumour and immunoregulatory effects of WGOS were evaluated in Hepatoma-22 (H22)-bearing mice. Treatment with WGOS inhibited tumour growth in vivo and significantly increased relative spleen and thymus weight, serum tumour necrosis factor-α level, spleen lymphocyte proliferation, natural killer cell activity, phagocytic function and nitric oxide production secreted by macrophage in H22-bearing mice. However, no direct cytotoxicity was detected. Therefore, the anti-tumour activity of WGOS may be related to their immunomodulatory effects.
从人参（Panax ginseng C.A. Meyer）中获得了由聚合度为2至14的D-葡萄糖组成的水溶性人参寡糖（WGOS）。在本研究中，对荷H22肝癌小鼠评估了WGOS的抗肿瘤和免疫调节作用。用WGOS治疗可抑制体内肿瘤生长，并显著增加荷H22肝癌小鼠的脾脏和胸腺相对重量、血清肿瘤坏死因子-α水平、脾脏淋巴细胞增殖、自然杀伤细胞活性、吞噬功能以及巨噬细胞分泌的一氧化氮产生。然而，未检测到直接的细胞毒性。因此，WGOS的抗肿瘤活性可能与其免疫调节作用有关。
