Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
Clinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
Vet Parasitol. 2014 Mar 17;201(1-2):24-30. doi: 10.1016/j.vetpar.2014.01.002. Epub 2014 Jan 11.
Canine babesiosis is a tick-borne disease with world-wide significance caused by intraerythrocytic protozoa of the genus Babesia. The eicosanoids, as inflammatory mediators, are involved in the regulation of the immune response and inflammatory reaction. Metabolism of lipids is of great importance in babesiosis. In this study it was aimed to investigate the dynamics of serum concentration of prostaglandin E2 (PGE2), thromboxane B2 (TxB2), leukotriene B4 (LTB4), triglycerides, total cholesterol (Chol), HDL- and LDL-cholesterol in dogs naturally infected with Babesia canis and healthy dogs. Both groups were measured for all parameters on the admission day and on the first, second and seventh day of the disease. Dogs that were included in this study had systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). It was demonstrated that the level of LTB4, PGE2, TxB2 in dogs naturally infected with B. canis significantly changed during the disease. The level of LTB4 was significantly higher during the study, while the concentration of PGE2 was significantly higher second, third and seventh day of disease in relation with healthy dogs. The level of TxB2 was significantly lower at the beginning of the disease, but after seven days concentration was significantly higher. Both group of patients with SIRS and MODS had significantly higher level of LTB4. Substained high concentrations of PGE2 were observed in dogs with MODS after therapy but not in dogs with SIRS, and LTB4 followed a similar tendency. On the other hand, increases in TxB2 were only significant in dogs with SIRS. The lipid profile in naturally infected dogs with B. canis infection was significantly changed. Further studies are needed to assess the prognostic values of lipid mediators in dogs with B. canis infection, and the ability of these markers to predict the progress of SIRS and MODS.
犬巴贝斯虫病是一种具有世界意义的蜱传疾病，由红细胞内原生动物巴贝斯虫属引起。类二十烷酸作为炎症介质，参与免疫反应和炎症反应的调节。脂质代谢在巴贝斯虫病中非常重要。本研究旨在研究自然感染犬巴贝斯虫的犬和健康犬血清中前列腺素 E2（PGE2）、血栓素 B2（TxB2）、白三烯 B4（LTB4）、甘油三酯、总胆固醇（Chol）、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的浓度动态。两组犬在入院当天和疾病第 1、2、7 天测量所有参数。纳入本研究的犬患有全身炎症反应综合征（SIRS）和多器官功能障碍综合征（MODS）。结果表明，自然感染犬巴贝斯虫的犬在疾病过程中 LTB4、PGE2、TxB2 水平显著变化。在研究过程中，LTB4 水平显著升高，而 PGE2 浓度在疾病的第 2、3、7 天与健康犬相比显著升高。TxB2 水平在疾病开始时显著降低，但 7 天后浓度显著升高。患有 SIRS 和 MODS 的两组患者的 LTB4 水平均显著升高。治疗后，MODS 犬的 PGE2 浓度持续升高，但 SIRS 犬无此变化，LTB4 也呈现类似趋势。另一方面，只有 SIRS 犬的 TxB2 升高有统计学意义。自然感染犬巴贝斯虫的犬脂质谱明显改变。需要进一步研究以评估脂质介质在犬巴贝斯虫感染中的预后价值，以及这些标志物预测 SIRS 和 MODS 进展的能力。
