Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.
Chem Commun (Camb). 2014 Mar 11;50(20):2650-2. doi: 10.1039/c4cc00029c.
Biologically interesting fused oligocyclic lactams have been prepared via an intramolecular redox-neutral cyclization process. By the proper choice of the substrates with a wide variety of tethered olefins, the less favored C-H bond can be activated and functionalized. This C-H activation proceeds under mild conditions, obviates the need for external oxidants, and displays a broad scope with respect to the substituents.
生物活性融合稠环内酰胺可通过分子内氧化还原中性环化过程制备。通过选择具有多种连接烯烃的底物，可激活和官能化不太有利的 C-H 键。这种 C-H 激活在温和条件下进行，无需外部氧化剂，并对取代基具有广泛的适用性。
