一种用于钌催化分子内烯烃氢芳基化反应的导向基团策略。
A tethering directing group strategy for ruthenium-catalyzed intramolecular alkene hydroarylation.
作者信息
Kilaru Praveen, Acharya Sunil P, Zhao Pinjing
机构信息
Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58108-6050, USA.
出版信息
Chem Commun (Camb). 2018 Jan 23;54(8):924-927. doi: 10.1039/c7cc08704g.
Abstract
We report a new catalyst design for N-heterocycle synthesis that utilizes an alkene-tethered amide moiety as a directing group for aromatic C-H activation. This tethering directing group strategy is demonstrated in a ruthenium-catalyzed intramolecular alkene hydroarylation with N-aryl acrylamides to form oxindole products.
摘要
我们报道了一种用于氮杂环合成的新型催化剂设计，该设计利用烯烃连接的酰胺部分作为芳香碳氢键活化的导向基团。这种连接导向基团策略在钌催化的N-芳基丙烯酰胺分子内烯烃氢芳基化反应中得到了验证，该反应生成了氧化吲哚产物。
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