Department of Biomaterials and Bioinspired Materials, Instituto de Ciencia de Materiales de Madrid (ICMM)/CSIC, Sor Juana Inés de la Cruz 3, Cantoblanco, 28049 Madrid, Spain.
Phys Chem Chem Phys. 2014 Mar 14;16(10):4456-64. doi: 10.1039/c3cp54763a.
Methods for the quantitative determination of magnetic nanoparticles in biological matrices, in the frame of biomedical applications, are required to evaluate the particles biodistribution after systemic administration. AC magnetic susceptibility measurements are an alternative method to quantify magnetic nanoparticles in tissues, being able to provide also information on the particle transformations over time and allowing the distinction of the particles from other endogenous species such as the ferritin iron cores. The protocol for particle quantification using AC magnetic susceptibility measurements is described in detail in this article. A summary of synthesis routes towards magnetic nanoparticles is also provided.
方法的定量测定磁性纳米粒子在生物基质中，在生物医学应用的框架内，需要评估粒子的生物分布后，全身给药。交流磁化率测量是一种替代的方法来量化磁性纳米粒子在组织中，能够提供信息的粒子转化随时间的推移，并允许从其他内源性物质如铁蛋白的铁核心的粒子的区别。该协议的粒子定量使用交流磁化率测量在本文中详细描述。合成路线的总结对磁性纳米粒子也提供了。
