聚-β-(1→6)-N-乙酰葡糖胺的合成寡糖缀合物的制备
Preparation of synthetic oligosaccharide-conjugates of poly-β-(1→6)-N-acetyl glucosamine.
作者信息
Fekete Anikó, Eszenyi Dániel, Herczeg Mihály, Pozsgay Vince, Borbás Anikó
机构信息
Department of Organic Chemistry, University of Debrecen, PO Box 20, H-4010 Debrecen, Hungary.
Department of Pharmaceutical Chemistry, Medical and Health Center, University of Debrecen, PO Box 70, H-4010 Debrecen, Hungary.
出版信息
Carbohydr Res. 2014 Mar 11;386:33-40. doi: 10.1016/j.carres.2013.12.022. Epub 2014 Jan 8.
Staphylococcus aureus and Staphylococcus epidermidis are prominent bacterial pathogens of nosocomial infections. Both microorganisms colonize medical devices by forming adherent biofilms. Poly-β-D-(1→6)-N-acetyl-glucosamine (PNAG) is a surface polysaccharide antigen which was found on both S. aureus and S. epidermidis. Animal studies have proved that PNAG can elicit antibodies which protect against staphylococcal infections. We have presented the synthesis of di-, tetra- and hexasaccharide fragments of PNAG with formyl-heptyl aglycone and their attachment to bovine serum albumin (BSA) by reductive amination.
金黄色葡萄球菌和表皮葡萄球菌是医院感染中重要的细菌病原体。这两种微生物都通过形成附着性生物膜在医疗设备上定殖。聚-β-D-(1→6)-N-乙酰葡糖胺（PNAG）是一种表面多糖抗原，在金黄色葡萄球菌和表皮葡萄球菌中均有发现。动物研究证明，PNAG能引发可抵御葡萄球菌感染的抗体。我们已经展示了带有甲酰庚基糖苷配基的PNAG二糖、四糖和六糖片段的合成，以及通过还原胺化将它们连接到牛血清白蛋白（BSA）上的过程。
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